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Structural Biology PhD Projects, Programs & Scholarships

We have 213 Structural Biology PhD Projects, Programs & Scholarships



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We have 213 Structural Biology PhD Projects, Programs & Scholarships

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Molecular Glues as Novel Therapies for Cancer and Ageing

Background: The need for new medicines is greater than ever because of an ageing population and the complex clinical challenges brought about by drug resistance and/or side effects. Read more

Using cryo-EM and biophysical methods to characterise proteins involved in DNA repair to aid development of novel therapeutics

DNA double-strand breaks (DSBs) describe a break across both strands of DNA. This type of DNA damage can be catastrophic for cell survival as if not repaired correctly can lead to deletions, translocation, cell death and cancer. Read more

Using cryo-EM to understand DNA double-strand break repair

We are looking for an ambitious PhD student with interests in learning about structural biology and DNA repair. Our goal is to gain a greater understanding of DNA repair to develop future therapeutics for treatment of diseases, ageing and cancer. Read more

In situ and structural studies of ion channel behaviour in acute injury and fibrosis

Background: Fibrosis (scarring) is a common ageing-associated process that affects all organs. It results from major or persistent injury, and maintains tissue integrity but not function, so excessive or progressive fibrosis results in organ dysfunction. Read more

EASTBIO New chemical tools to understand and exploit tubulin diversity

Microtubules are long polymers important for cell division, intracellular transport and polarity. Many isotypes of microtubules co-exist in human cells and levels of expression vary with the cell type. Read more

EASTBIO Investigating the Assembly of Bacterial Encapsulins for the Efficient Engineering of Nanoscale Bioreactors

Encapsulins are bacterial capsid-like nanocompartments roughly 25-30 nm in diameter. These large protein assemblies are made up of either 60 or 180 copies of a single 30 kDa protomers which assemble to form a hollow icosahedral protein cage. Read more

EASTBIO Expanding the chemistry of non-heme enzymes

Chemical synthesis is widely viewed as being unsustainable. Whilst this is an oversimplification, in many cases chemical production still relies on petrochemicals, rare metals and high energy consumption to make the products we need for modern life. Read more

EASTBIO Bone biomineralisation

This project will investigate the fundamental mechanisms which regulate bone mineralisation through extracellular vesicles. A deeper understanding of this process will expose new therapeutic targets for the treatment of bone disorders. Read more

EASTBIO Biocatalyst cascades for drug synthesis

Project Details. Natural and engineered biocatalysts are already having impact in the manufacture of high value pharmaceuticals by catalysing the conversion of functional groups in high yield. Read more

EASTBIO An integrated approach to deciphering the role of proline in intrinsically disordered protein regions

Proteins often have a well-defined structure that is key to it performing their function. Intrinsically disordered regions (IDRs) have no defined 3D structure and are found in many proteins, yet their purpose is poorly understood. Read more

EASTBIO: Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signaling

Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more

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