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Synthetic Chemistry (human) PhD Projects, Programs & Scholarships

We have 20 Synthetic Chemistry (human) PhD Projects, Programs & Scholarships

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  Small molecule probes to study human enzymes involved in muscular dystrophy
  Dr L Willems, Dr M A Fascione
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Proteins on the surface of cells are often modified with diverse, complex carbohydrate structures. These carbohydrates, named glycans, play central roles in biology by regulating, for instance, cell recognition and signalling events.
  Antibody-drug conjugates (ADCs) for the treatment of solid tumours
  Dr S Karagiannis, Prof J Downward
Application Deadline: 29 November 2019

Funding Type

PhD Type

An Antibody-Drug Conjugate (ADC) comprises an antibody targeted toward a tumour cell surface antigen, coupled through a chemical linker to a highly-cytotoxic drug.
  Chemical protein labeling approaches to study TRPC5 channel regulation in adipocytes.
  Research Group: BBSRC White Rose DTP
  Dr R.S. Bon, Prof A J Wilson, Dr P Sukumar
Application Deadline: 6 January 2020

Funding Type

PhD Type

The protein TRPC5 forms homo- and heterotetrameric cation channels that play key roles in cellular signalling and responses to chemical and physical environmental factors, and its implication in human disease (including anxiety disorders, kidney disease and obesity) has resulted in TRPC5 channels emerging as potential therapeutic targets.
  Designing novel composite polysaccharide nanoparticles for combined diagnosis and treatment of cancers
  Dr E Barbu, Dr A Lalatsa
Applications accepted all year round

Funding Type

PhD Type

Cancer continues to impose a vast burden with regard to financial costs as well as human suffering but the progress in its treatment is hindered by the limited selectivity and significant side-effects that the current chemotherapy demonstrates, representing a major challenge for modern drug delivery.
  Developing an enzymatic toolbox to make complex modified peptides
  Prof M Jaspars, Dr W Houssen, Dr L Trembleau
Applications accepted all year round

Funding Type

PhD Type

The pharmaceutical industry has identified a major gap in its portfolio. On the one hand, they are excellent at discovering small molecules that act via a lock and key type mechanism.
  Genome mining of novel antimicrobial natural products from new bacterial strains
  Dr H Deng, Prof M Jaspars
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
  Chemically editable 3D tumour microenvironments to explore and exploit tumour immunity
  Dr O Pearce, Dr B Schumann
Application Deadline: 29 November 2019

Funding Type

PhD Type

Immunotherapy of cancers may offer progression free survival that is not seen with conventional chemotherapies. However, immunological barriers present within the tumour reduce response rates to therapy.
  Developing polymer-based diagnostics for bacterial disease
  Dr CS Mahon
Application Deadline: 31 December 2019

Funding Type

PhD Type

Modern healthcare has enabled vast improvements in human life expectancy and quality of life, yet a significant barrier to further improvements in treatments of many diseases is the lack of rapid diagnostic tests to enable their timely identification.
  Synthesis and computation to understand and redesign self-assembling carbohydrate materials
  Prof R Field, Dr A Almond
Application Deadline: 31 January 2020

Funding Type

PhD Type

Polysaccharides are widespread in nature and fulfil many important biological functions; they are important foodstuffs and they are exploited as bulk commodities across industry sectors due to their physical properties.
  Synthetic and Mechanistic Studies into Enzymatic Degradation of Waste Plastics
  Dr L Wong, Dr C F Blanford
Applications accepted all year round

Funding Type

PhD Type

Plastics are a broad range of solid polymeric materials that have found widespread application as industrial components and consumer goods.
  (BBSRC DTP) Selective knockdown of proinflammatory microRNAs to tackle neurodegeneration and cognitive decline: myth or reality?
  Dr E Bichenkova, Prof J Neill, Dr F Roncaroli, Prof D Clarke
Application Deadline: 31 January 2020

Funding Type

PhD Type

Neurodegenerative diseases (e.g. multiple and amyotrophic lateral sclerosis, Alzheimer’s and Parkinson’s diseases) have tremendous psychological, clinical and social impact, which becomes increasingly challenging in the global trend of population aging.
  Tyrosine kinase inhibitors conjugated tumour targeting dyes for the treatment of glioblastoma.
  Dr J Jose, Dr P Choi
Applications accepted all year round

Funding Type

PhD Type

Glioblastoma (GBM) remains a lethal and difficult to treat cancer with a dismal outcome. Although we have a better understanding of the disease progression, a concurrent increase in therapeutic intervention is lagging.
  Bio-inspired ceramic composites for dental and orthopaedic applications
  Prof B Su, Dr M E Barbour
Applications accepted all year round

Funding Type

PhD Type

Natural structural materials such as seashell nacre, human teeth and bones exhibit remarkable mechanical properties i.e. with combined high strength and toughness.
  Precision Medicine DTP - High-Precision Tools for Intraoperative Brain Cancer Surgery
  Research Group: Centre for Inflammation Research
  Dr M Vendrell Escobar, Dr P Brennan, Dr C Portal
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Glioblastomas are one of the most common and aggressive brain cancers. Current treatments provide a mean survival of 14 months, with most tumours recurring post-resection.
  Inhibitors of cilia and Hedgehog signaling: from phenotype to mechanistic understanding
  Prof S Hoogendoorn
Applications accepted all year round

Funding Type

PhD Type

The Hedgehog (Hh) signaling pathway is a major contributor to embryonic development, and tissue homeostasis and stem cell maintenance in children and adults.
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