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Synthetic Chemistry (synthetic biology) PhD Projects, Programs & Scholarships

We have 31 Synthetic Chemistry (synthetic biology) PhD Projects, Programs & Scholarships

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  Protein nanocompartments for advanced enzymatic catalysis (PhD in Chemical and Synthetic Biology)
  Dr Y H Lau
Applications accepted all year round

Funding Type

PhD Type

The University of Sydney is looking for outstanding candidates who are looking to apply for a PhD position in chemical and synthetic biology, in the group of Dr Yu Heng Lau (http://sydney.edu.au/science/people/yuheng.lau.php).
  Synthetic Biology of the peroxisome
  Research Group: BBSRC White Rose DTP
  Prof A Baker, Dr S Warriner
Application Deadline: 6 January 2020

Funding Type

PhD Type

Compartmentalisation is a fundamental feature of eukaryotic cells and increases efficiency and complexity by segregating incompatible reactions and concentrating intermediates.
  Towards artificial signal transduction in living cells
  Dr S Webb
Applications accepted all year round

Funding Type

PhD Type

The development of synthetic molecules able to transmit biochemical information across phospholipid bilayers could lead to a new type of synthetic biology, where the introduction of orthogonal signalling pathways leads to ‘short-circuiting’ of natural signalling networks in cells.
  (BBSRC DTP CASE) Discovery and Engineering of Expanded Halogenases for Late Stage Enzymatic Functionalisation
  Prof J Micklefield, Prof P Barran
Application Deadline: 31 January 2020

Funding Type

PhD Type

The project aims to discover and engineer novel enzymes (biocatalysts) that can affect regioselective halogenation of complex molecules enabling more efficient and environmentally sustainable production of pharmaceuticals which are urgently required to combat disease.
  (BBSRC DTP) Discovery and Editing Pathways to New Antibiotics
  Prof J Micklefield, Prof D Leys, Dr A Green
Application Deadline: 31 January 2020

Funding Type

PhD Type

There is an urgent need for new antibiotics. The majority of antibiotics that are used to treat infectious diseases today are small molecules produced by microorganisms, called natural products, or derivatives thereof.
  Elucidating plant alkaloid biosynthesis
  Dr B R Lichman, Dr W Unsworth
Application Deadline: 30 June 2020

Funding Type

PhD Type

Plants are capable of forming complex natural products from simple starting materials. Many of these natural products are bioactive, but access is limited as they are difficult to synthesise using organic chemistry and are present in small quantities in the natural source.
  Artificial metalloenzyme design with late transition metal active sites
  Dr A Peacock, Dr P Davies
Application Deadline: 15 December 2019

Funding Type

PhD Type

This PhD project involves the rational design, preparation and assessment of artificial metalloenzymes. Nature’s catalysts, enzymes, have been perfected by evolution to perform reactions under mild conditions and with enviable asymmetric control and selectivity.
  PhD in Chemical Biology -- Neuropeptide Research -- University of Vienna
  Prof M Muttenthaler
Applications accepted all year round

Funding Type

PhD Type

Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases.
  Synthetic and Mechanistic Studies into Enzymatic Degradation of Waste Plastics
  Dr L Wong, Dr C F Blanford
Applications accepted all year round

Funding Type

PhD Type

Plastics are a broad range of solid polymeric materials that have found widespread application as industrial components and consumer goods.
  Development of novel tools that bind intrinsically disordered regions to manipulate clinically important targets
  Prof J Waltho, Dr A Almond
Application Deadline: 12 January 2020

Funding Type

PhD Type

Dual award PhD in Synthetic and Systems Biology - Manchester and Tsinghua University.
  Electrochemically Driven Deoxydehydration Reactions
  Dr J Taylor
Application Deadline: 9 February 2020

Funding Type

PhD Type

A PhD position is available to work with Dr James Taylor at the University of Bath on a project focused on the development of new catalytic processes for the deoxydehydration of diols using modern electrosynthetic technology.
  The chemical glycobiology of carbohydrate metabolism
  Prof R Field, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Carbohydrates are widespread in nature and fulfil many important biological functions. However, the biology of carbohydrates is much less well explored than that of nucleic acids and proteins.
  Identification and Characterisation of bile salt binding proteins in Clostridium difficile spores: their role in triggering germination
  Dr S Kuehne, Dr G Poologasundarampillai
Application Deadline: 12 January 2020

Funding Type

PhD Type

Background. Clostridium difficile infection (CDI) is a leading cause of hospital-associated and acquired diarrhoea, leading to high morbidity and mortality.
  Deciphering the glycocode – application of synthetic probes to study protein-carbohydrate interactions
  Research Group: BBSRC White Rose DTP
  Prof W B Turnbull, Dr G.R. Hemsworth
Application Deadline: 6 January 2020

Funding Type

PhD Type

All living cells are covered in a coating of complex carbohydrates (glycans) that are attached to lipids and proteins. Specific glycolipids play important roles in controlling cell differentiation, ion transport and cell signaling.
  Chemical Tools to Understand and Manipulate the Function of Intrinsically Disordered Regions of Proteins
  Research Group: BBSRC White Rose DTP
  Prof A J Wilson, Prof S E Radford
Application Deadline: 6 January 2020

Funding Type

PhD Type

A key problem in life-sciences research is to understand biomacromoleular function in molecular and temporal resolution – this would provide unprecedented understanding of the molecular mechanisms of health and disease.
  Developing an enzymatic toolbox to make complex modified peptides
  Prof M Jaspars, Dr W Houssen, Dr L Trembleau
Applications accepted all year round

Funding Type

PhD Type

The pharmaceutical industry has identified a major gap in its portfolio. On the one hand, they are excellent at discovering small molecules that act via a lock and key type mechanism.
  Development of Optical Nanobiosensors for Opioids and Fentanyl-related Substances
  Dr O Adegoke, Prof N Nic Daeid
Applications accepted all year round

Funding Type

PhD Type

Opioid use is currently on the increase and its abuse poses serious risks that affects the economic state of all societies worldwide as well as health and social wellbeing.
  MRC DiMeN Doctoral Training Partnership: Software, Synthesis and Screening: cheminformatic led invention, design and synthesis of novel compounds for the treatment of septic shock
  Prof JPA Harrity, Dr G Richards, Dr A Hogben, Dr A Pannifer
Application Deadline: 6 January 2020

Funding Type

PhD Type

Industrial and academic medicinal chemists take advantage of modern cheminformatic and biology technologies to inform and guide their science.
  Small molecule probes to study human enzymes involved in muscular dystrophy
  Dr L Willems, Dr M A Fascione
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Proteins on the surface of cells are often modified with diverse, complex carbohydrate structures. These carbohydrates, named glycans, play central roles in biology by regulating, for instance, cell recognition and signalling events.
  Stereoselective nucleoside fluorination methodology for the development of next-generation oligonucleotide therapeutics
  Prof G Burley
Application Deadline: 17 January 2020

Funding Type

PhD Type

Background. Oligonucleotide (ON) therapeutics is an exciting clinically-approved platform for the treatment of a range of diseases not readily accessible by small molecule drugs.
  Development of magnetic nanoparticles for in vivo tissue regeneration
  Dr D Ungar, Prof P G Genever
Application Deadline: 30 June 2020

Funding Type

PhD Type

The regeneration of injured tissues can best be achieved through the action of appropriate stem cells that proliferate and differentiate to heal the injury.
  Chemo-enzymatic Synthesis and Potential Applications of Novel Heterocyclic Alkaloids
  Dr H Deng, Dr L Trembleau
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
  Novel strategies for the diagnosis and treatment of snakebites
  Dr S Vaiyapuri
Applications accepted all year round

Funding Type

PhD Type

Snakebites represent a major neglected tropical disease affecting several million people worldwide and resulting in as many as 150000 deaths each year.
  (BBSRC DTP) Tackling the genomic dark matter through system engineering of ncRNAs in yeast
  Prof D Delneri, Prof P Cai
Application Deadline: 31 January 2020

Funding Type

PhD Type

Non-coding RNAs (ncRNAs) are thought as of genomic "dark matter" for which the biological significance has been largely underestimated.
  Polymeric Hydrogels for Regenerative Medicine Applications
  Dr P De Bank
Applications accepted all year round

Funding Type

PhD Type

Regenerative medicine aims to repair injured or diseased tissues using a multidisciplinary approach to stimulate natural repair mechanisms or promote healing through the transplantation of cells, often the patient’s own stem cells.
  Natural product-inspired fragments
  Dr D Foley
Applications accepted all year round

Funding Type

PhD Type

Key words. drug discovery; natural products; medicinal chemistry; organic synthesis. Motivated international and New Zealand-based candidates are invited to apply for a PhD Scholarship to investigate the synthesis and biological evaluation of a natural product-inspired fragment collection.
  Designing novel composite polysaccharide nanoparticles for combined diagnosis and treatment of cancers
  Dr E Barbu, Dr A Lalatsa
Applications accepted all year round

Funding Type

PhD Type

Cancer continues to impose a vast burden with regard to financial costs as well as human suffering but the progress in its treatment is hindered by the limited selectivity and significant side-effects that the current chemotherapy demonstrates, representing a major challenge for modern drug delivery.
  Raman probes to determine cellular redox potential
  Prof N Tomkinson, Prof S Mackay
Application Deadline: 30 March 2020

Funding Type

PhD Type

The discovery of novel medicines to treat disease requires the identification, understanding and validation of new biological pathways and targets.
  Exploring organic materials chemistry is available in the Peeks group at UNSW
  Dr M Peeks
Applications accepted all year round

Funding Type

PhD Type

We are exploring the properties and applications of aromatic and antiaromatic molecules, with a particular interest in seeing how unusual (anti)aromatic building blocks can be combined, including in supramolecular assemblies, to deliver new properties.
  Structure based design of novel warheads for use in peptide-drug conjugates
  Dr S Butterworth, Dr A Tirella, Dr D Wiseman
Applications accepted all year round

Funding Type

PhD Type

Chronic Myelomonocytic Leukaemia (CMML) is an orphan disease defined by myeloid dysplasia, myeloproliferation and a malignant expansion of classical monocytes.
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