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We have 13 Synthetic Chemistry (scaffolds) PhD Projects, Programmes & Scholarships
Synthetic Chemistry (scaffolds) PhD Projects, Programmes & Scholarships
We have 13 Synthetic Chemistry (scaffolds) PhD Projects, Programmes & Scholarships
Photochemical synthesis of new drug-like scaffolds
Our laboratory is interested in the application of enabling technologies, such as continuous flow[1] and photochemistry,[2] for the synthesis of useful functional molecules such as drugs, agrochemicals and materials. Read more
P28. Late-Stage Oxygenation of Medicinally Important Bridged Bicyclic Hydrocarbons using Unspecific Peroxygenases (UPOs) (CSHP CDT)
We will establish methods for the synthesis of novel, medicinally important bridged bicyclic hydrocarbon (BBH) scaffolds using late-stage oxygenation enabled by unspecific peroxygenase (UPO) enzymes. Read more
P17. sp3–sp2 Suzuki-Miyaura Cross Coupling of Heterocyclic Organoborons: Exploring 3D Pharmaceutical Space (CSHP CDT)
There is significant interest in sp3-rich heterocyclic scaffolds for medicinal chemistry and there is thus a need for methods to construct sp3-sp2 bonds on such scaffolds in a simple, controllable, programmable and sustainable way. Read more
P16. Systematic Exploration of 3D Pharmaceutical Space using 3D Bifunctional Building Blocks (CSHP CDT)
There is much interest in 3D heterocyclic scaffolds for medicinal chemistry. Within fragment-based drug discovery, we are developing a synthetic platform to enable the elaboration of 2D fragments into 3D lead compounds, addressing limitations highlighted by industry. Read more
PhD Position in Fundamental and Applied Chemistry of PN Cages
Background. Our group explores geometrically interesting molecules for fundamental and functional chemistry. One area of focus is the development of scaffolds from which substituents can be reliably extended with well-defined bond angles and lengths. Read more
P21. Radical polar crossover from the triplet state (CSHP CDT)
New reaction manifolds are valuable for the synthesis of complex molecules. This project will focus on the development of radical-polar crossover reactions by employing visible light mediated energy transfer catalysis to generate complex three-dimensional heterocyclic scaffolds. Read more
P7. Metal catalysed synthesis of complex stereochemically defined nitrogen heterocycles (CSHP CDT)
This project contains exciting opportunities for the production of complex stereochemically defined ‘3D’ heterocycles from simple, easily prepared, ‘2D’ aromatic precursors. Read more
Non-invasive Therapy for Soft Tissue Reconstruction: Applications in Cosmetics and Wound Healing
Soft tissue reconstruction is emerging as an important strategy to repair and replace diseased or damaged tissue that has been compromised due to tumour removal, injury, trauma, ageing, etc. Read more
Optical Tissue Stimulation for In vitro Vascularization
At the Programmable Biomaterials Lab (PBL), our goal is to solve some of the major challenges facing large-scale and high-throughput bioproduction via innovative 3D light-assisted programming of matter. Read more
Design of metallo coiled coil MRI contrast agents
This PhD project will develop a new class of MRI contrast agents. MRI is an essential tool for medical diagnosis. Contrast agents play a crucial role in improving the images obtained, and hence patient outcomes. Read more
Design and study of modified peptide foldamers
These projects are open to students worldwide, but have no funding attached. Therefore, the successful applicant will be expected to fund tuition fees at the relevant level (home or international) and any applicable additional research costs. Read more
Nanomedicines Prepared using Polymerization Induced Self-Assembly (PISA)
Background. Recent advances in polymer particle design have largely relied on developments in controlled/living or reversible deactivation radical polymerization (RDRP). Read more
EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis (TECS)
Our PhD programme combines world-leading research in Chemical Synthesis with state-of-the-art training in technology and automation to prepare you for a career in modern synthetic chemistry, whether in industry or academic research. Read more
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