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We have 229 Synthetic Chemistry PhD Projects, Programmes & Scholarships
Synthetic Chemistry PhD Projects, Programmes & Scholarships
We have 229 Synthetic Chemistry PhD Projects, Programmes & Scholarships
P21. Radical polar crossover from the triplet state (CSHP CDT)
New reaction manifolds are valuable for the synthesis of complex molecules. This project will focus on the development of radical-polar crossover reactions by employing visible light mediated energy transfer catalysis to generate complex three-dimensional heterocyclic scaffolds. Read more
P2. New applications of thiophene-S,S-dioxides in sustainable synthesis (CSHP CDT)
Thiophene S,S-dioxides (TDOs) are convenient but underutilised building blocks in organic chemistry. This project will seek to develop new applications of TDOs in sustainable chemical synthesis. Read more
P19. Combatting Antimicrobial Resistance (CSHP CDT)
Resistance to pharmaceuticals, including anti-infectives and cancer drugs, and agrochemicals is a major global health problem. As highlighted by the 2016 O’Neill report, the situation with current antibiotics is perilous. Read more
P18. Synthesis of Aryl-fused Bicyclo[3.1.1]heptanes (BCHeps) and Validation as Heterobiaryl Bioisosteres (CSHP CDT)
While naphthalene and equivalent heterobiaryl rings are often encountered in drugs, candidates and lead molecules, they can be susceptible to cytochrome P450-mediated metabolism and exhibit flat, sp2-rich structures and are almost invariably derived from fossil fuel sources, limiting their current and future utility. Read more
P15. Sustainable Hydrogen Borrowing Catalysis with Earth Abundant Metals (CSHP CDT)
While hydrogen borrowing (HB) catalysis offers an attractive route for the construction of C-C bonds using alcohols and ketones, current methods rely upon… Read more
P14. Next generation antibiotic siderophores (CSHP CDT)
This project will develop next generation synthetic siderophores - small molecule high affinity iron receptors used by bacteria to accumulate iron. Read more
P13. Micellar organo-catalysis in water using earth abundant main group elements (CSHP CDT)
This project will explore methods to use earth abundant, Lewis acidic main group catalysts to catalyse organic transformations in water by exploiting micellar confinement. Read more
P11. The development of photodynamic surfactants: a new modality to tackle anti-microbial resistance (CSHP CDT)
There is increasing interest in the use of surfactants to tackle key elements of antimicrobial resistance (AMR). Read more
P10. Catalytic asymmetric cross-coupling reactions using non-precious metals (CSHP CDT)
Asymmetric cross-coupling technologies are powerful techniques that represent the state-of-the-art in the construction of chiral small molecules. Read more
P1. Improving the sustainability of propellane chemistry (CSHP CDT)
Bicyclo[n.1.1]alkanes (BCAs) have emerged as important building blocks in contemporary drug design, serving as useful building blocks that can substitute for aromatic rings, leading to improved physicochemical and pharmacokinetic profiles of drug candidates. Read more
P4. Green Polymers from Sugars towards Polyethylene-Like Materials (CSHP CDT)
Polymers are widespread in modern society as they produce light, strong, and cheap plastic materials, with an ever-increasing demand, which are critical to many technologies from consumer goods, electronics to healthcare. Read more
P28. Late-Stage Oxygenation of Medicinally Important Bridged Bicyclic Hydrocarbons using Unspecific Peroxygenases (UPOs) (CSHP CDT)
We will establish methods for the synthesis of novel, medicinally important bridged bicyclic hydrocarbon (BBH) scaffolds using late-stage oxygenation enabled by unspecific peroxygenase (UPO) enzymes. Read more
P27. An exploration of “greener” alternatives for oligonucleotide synthesis (CSHP CDT)
The solid phase synthesis of oligonucleotides, historically conducted on controlled pore glass, but more recently on polystyrene, typically proceeds in a 3′ to 5′ direction by a four-step synthesis cycle with each step followed by a solvent wash. Read more
P26. Metal-free catalysis to make and break C-F bonds (CSHP CDT)
Fluorine-containing molecules are essential in a wide range of applications, including in many pharmaceuticals and agrochemicals. Read more
P16. Systematic Exploration of 3D Pharmaceutical Space using 3D Bifunctional Building Blocks (CSHP CDT)
There is much interest in 3D heterocyclic scaffolds for medicinal chemistry. Within fragment-based drug discovery, we are developing a synthetic platform to enable the elaboration of 2D fragments into 3D lead compounds, addressing limitations highlighted by industry. Read more