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We have 233 Synthetic Chemistry PhD Projects, Programmes & Scholarships
Synthetic Chemistry PhD Projects, Programmes & Scholarships
We have 233 Synthetic Chemistry PhD Projects, Programmes & Scholarships
Last chance to apply
P10. Catalytic asymmetric cross-coupling reactions using non-precious metals (CSHP CDT)
Asymmetric cross-coupling technologies are powerful techniques that represent the state-of-the-art in the construction of chiral small molecules. Read more
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P1. Improving the sustainability of propellane chemistry (CSHP CDT)
Bicyclo[n.1.1]alkanes (BCAs) have emerged as important building blocks in contemporary drug design, serving as useful building blocks that can substitute for aromatic rings, leading to improved physicochemical and pharmacokinetic profiles of drug candidates. Read more
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P4. Green Polymers from Sugars towards Polyethylene-Like Materials (CSHP CDT)
Polymers are widespread in modern society as they produce light, strong, and cheap plastic materials, with an ever-increasing demand, which are critical to many technologies from consumer goods, electronics to healthcare. Read more
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P28. Late-Stage Oxygenation of Medicinally Important Bridged Bicyclic Hydrocarbons using Unspecific Peroxygenases (UPOs) (CSHP CDT)
We will establish methods for the synthesis of novel, medicinally important bridged bicyclic hydrocarbon (BBH) scaffolds using late-stage oxygenation enabled by unspecific peroxygenase (UPO) enzymes. Read more
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P27. An exploration of “greener” alternatives for oligonucleotide synthesis (CSHP CDT)
The solid phase synthesis of oligonucleotides, historically conducted on controlled pore glass, but more recently on polystyrene, typically proceeds in a 3′ to 5′ direction by a four-step synthesis cycle with each step followed by a solvent wash. Read more
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P26. Metal-free catalysis to make and break C-F bonds (CSHP CDT)
Fluorine-containing molecules are essential in a wide range of applications, including in many pharmaceuticals and agrochemicals. Read more
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P16. Systematic Exploration of 3D Pharmaceutical Space using 3D Bifunctional Building Blocks (CSHP CDT)
There is much interest in 3D heterocyclic scaffolds for medicinal chemistry. Within fragment-based drug discovery, we are developing a synthetic platform to enable the elaboration of 2D fragments into 3D lead compounds, addressing limitations highlighted by industry. Read more
Sending a message down a golden thread
Background. Transmembrane receptors in cell membranes, like G-protein coupled receptors (GPCRs), relay chemical messages into cells in a process called “signal transduction”. Read more
Probing the f→d transition in lanthanide ions for qubit switching
Metal centres with single unpaired electrons have great potential as qubit systems; the two spin-states of the electron (up and down) can be mapped onto classical bits 0 and 1, with additional superpositions of the states allowing for increased computational speed following Quantum Information Processing (QIP) algorithms compared to classical computer systems. Read more
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Interlocked Oligonucleotides for Chemical Biology and Medicine
Background. Rotaxanes, molecules in which a linear component is trapped within a ring-shaped molecule like a bead on a thread, and catenanes, molecules formed of two rings threaded through one another like links in a chain, are the archetypal interlocked molecules. Read more
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Mechanically Interlocked Ligands for Medical Imaging
Background – metal coordination and the mechanical bond. Interlocked molecules made using metal-templated approaches are mechanically chelating ligands (1) for transition metal ions. Read more
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Entangled polymers with designer properties
Background – polycatenane synthesis is an unsolved problem. Linking rings in a chain is a familiar idea in the macroscopic world and the equivalent concept has been discussed at a molecular level for over a century. Read more
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Mechanically interlocked chiral molecules for sensing and catalysis
Background – mechanical stereochemistry. The stereoselective synthesis of chiral organic molecules is one of the core challenges in synthetic organic chemistry. Read more
Injectable biomimetic hydrogels
As the population ages and chronic illnesses rise, innovative solutions in tissue engineering are becoming increasingly vital for improving health outcomes. Read more
Control of Relaxation Times in Rare Earth Single-Molecule Magnets and Qubits
An EPSRC DTG-sponsored PhD studentship is available for an outstanding and ambitious chemist to undertake research in the field of synthetic inorganic chemistry in a collaborative project between three research groups at Manchester Chemistry. Read more