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We have 78 Synthetic Chemistry PhD Projects, Programmes & Scholarships for UK Students
Synthetic Chemistry PhD Projects, Programmes & Scholarships for UK Students
We have 78 Synthetic Chemistry PhD Projects, Programmes & Scholarships for UK Students
Csp3-H Zincation: Functional Group Tolerant Modifications of Pharmaceutical Moieties
Selective C-H functionalisation is a gold-standard reaction in synthetic chemistry for pharmaceutical and natural product synthesis, adding complexity and value to simple starting materials while generating the minimum possible waste. Read more
Improving the sustainability of propellane chemistry
Bicyclo[n.1.1]alkanes (BCAs) have emerged as important building blocks in contemporary drug design, serving as useful building blocks that can substitute for aromatic rings, leading to improved physicochemical and pharmacokinetic profiles of drug candidates. Read more
Late-Stage Oxygenation of Medicinally Important Bridged Bicyclic Hydrocarbons using Unspecific Peroxygenases (UPOs)
We will establish methods for the synthesis of novel, medicinally important bridged bicyclic hydrocarbon (BBH) scaffolds using late-stage oxygenation enabled by unspecific peroxygenase (UPO) enzymes. Read more
Functional Sugar-derived Polymers for Sustainable Agricultural Applications
Beyond plastics, polymers play a vital role in our lives as key ingredients of liquid formulations. Read more
Stable Organometallic Gels for sp3-sp2 and sp2-sp2 Negishi Cross-Coupling
Air- and moisture-sensitive organometallic reagents are a key tool in modern synthetic chemistry and enable a wide range of powerful synthetic transformations. Read more
sp3–sp2 Suzuki-Miyaura Cross Coupling of Heterocyclic Organoborons: Exploring 3D Pharmaceutical Space
There is significant interest in sp3-rich heterocyclic scaffolds for medicinal chemistry and there is thus a need for methods to construct sp3-sp2 bonds on such scaffolds in a simple, controllable, programmable and sustainable way. Read more
Systematic Exploration of 3D Pharmaceutical Space using 3D Bifunctional Building Blocks
There is much interest in 3D heterocyclic scaffolds for medicinal chemistry. Within fragment-based drug discovery, we are developing a synthetic platform to enable the elaboration of 2D fragments into 3D lead compounds, addressing limitations highlighted by industry. Read more
The development of better drugs for heart failure
History and purpose. Are you passionate about cutting-edge drug development and eager to make a real-world impact? The Ferrier Research Institute at Victoria University of Wellington is offering an exciting PhD scholarship to help transform the treatment of heart failure. Read more
Design and synthesis of transition-state analogue inhibitors of 2’-deoxynucleoside 5’-phosphate N-glycosidase 1 (DNPH1)
History and purpose. Cancer is the leading cause of death in New Zealand and worldwide, associated with one in three deaths. Despite the emergence of immunotherapies, cancer patients are largely treated using conventional cancer therapies such as surgery, radiation, and chemotherapies. Read more
Green Polymers from Sugars towards Polyethylene-Like Materials
Polymers are widespread in modern society as they produce light, strong, and cheap plastic materials, with an ever-increasing demand, which are critical to many technologies from consumer goods, electronics to healthcare. Read more
An exploration of “greener” alternatives for oligonucleotide synthesis
The solid phase synthesis of oligonucleotides, historically conducted on controlled pore glass, but more recently on polystyrene, typically proceeds in a 3′ to 5′ direction by a four-step synthesis cycle with each step followed by a solvent wash. Read more
Developing and understanding organometallic late transition metal complexes for C-H and C-C activation
The Mansell research group are currently looking at two systems that are capable of reactions with some of the least reactive bonds known, specifically… Read more
The discovery of robust septin binders to validate their potential as a future drug target
Commercial partner: Jazz Pharmaceuticals . Septins are filamentous GTPases that associate with cell membranes and the cytoskeleton (actin, microtubules), and play essential roles in cell division and cellular morphogenesis. Read more
EPSRC funded PhD in Chemistry - Catalysis under Pressure - Free Radical Detection by EPR
Sustainable Chemistry has revolutionized the way in which products and processes are produced. In simple terms, sustainability in the chemical sciences seeks to enhance the efficiency of natural resources supporting the production of a greener and more resource-efficient future. Read more
Polymer Materials to Store Biologics at Room Temperature
Biologics are cell and protein-based therapies which are transforming medical outcomes. This spans insulin for diabetes, glucagon-like peptides for obesity, CAR-T cells for cancer and more. Read more