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Toxicology PhD Projects, Programmes & Scholarships

We have 63 Toxicology PhD Projects, Programmes & Scholarships

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We have 63 Toxicology PhD Projects, Programmes & Scholarships

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Systems Biology of Cellular Stress Response

Our cells are exposed to a large number of chemicals such as food additives, water contaminants and pollution in the air etc. Exposure to many of these leads to toxic effect and in some cases cancer and other diseases. Read more

Exploiting genetic defects in ovarian clear cell carcinoma for therapeutic purposes

We are seeking a talented and enthusiastic PhD candidate to lead a project to identify and characterise novel therapeutic strategies for ovarian cancer. Ovarian cancer is the deadliest of all gynaecological cancers. Read more

Design of a buccal patch for delivery of a GLP-1 peptide

Delivery of peptides via non-injected routes remains an unmet medical need. Delivery across the cheek is attractive and has some advantages over oral including avoidance of a food effect and a lower first pass effect. We have discovered a permeation enhancer that can be incorporated into a buccal patch system (. Read more

Air pollution lung health effects and the rising use of renewable fuels

About the Project. Air pollution is the leading environmental risk factor for mortality in England. An equivalent to 32,000 deaths is estimated annually with emissions from transport combustion engines a particular cause for concern. Read more

Synthetic transition metal catalysts for the treatment of cancer

Working the interfaces of chemical catalysis, analytical chemistry, cellular biology, pharmacology and medicine, this project provides unique interdisciplinary training in the skills required for the development of a pre-clinical metal-based therapy. Read more

A biologic drug blocking ROR2 for disease modification in osteoarthritis

We reported that silencing the WNT receptor ROR2 results in protection from cartilage breakdown and rapid pain relief in a murine model of osteoarthritis and in chondrogenesis in vitro and in vivo with human osteoarthritic chondrocytes (Thorup et al. Read more

Cell-type dependent pharmacological regulation of cellular mitophagy for therapeutic application in Parkinson’s disease

The cellular quality-control process of mitophagy, entailing selective degradation of defective mitochondria (following damage to their DNA) by the process of autophagy, has attracted considerable research interest. Read more

Targeting protein acetylation to reduce microglia activation in neurodegenerative disorders

Recently, inhibitors of histone deacetylase enzymes (HDACs) have been identified as having potential therapeutic value for a range of neuronal disorders including Alzheimer’s disease, dementia and stroke [1, 2]. Read more

Understanding why cardiovascular dysfunction is one of the leading causes of mortality in patients with Non-Alcoholic Fatty Liver disease (NAFLD)

Background. Liver disease accounts for 3.5% of all global deaths/year (~2 million people) and is the third leading cause of premature death in the UK with some of the highest hospitalisations in the country seen in areas of socioeconomic deprivation. Read more

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