About. The BBSRC-funded SWBio DTP involves a partnership of world-renown universities, research institutes and industry, based mainly across the South West and Wales. Read more
In complex biological systems, checkpoints ensure that critical components are functioning correctly. A great example of this is our immune system, which must integrate signals from multiple cell-types to protect us from invading pathogens. Read more
Primary supervisor - Dr Anastasia Sobolewski. Non-small cell lung cancer (NSCLC) is diagnosed at a late stage and has a poor prognosis. Although some targeted treatments exist, chemoresistance frequently occurs. One mechanism through which chemoresistance can happen is through tunnelling nanotubes (TNTs). Read more
Embryonic tissues and organs are shaped and patterned by complex genetic, molecular and cellular mechanisms that regulate essential processes during development [1]. Read more
Background. biomedical application of fish oil-derived omega-3 fatty acids. Dietary intake of omega-3 polyunsaturated fatty acids from fish oils has been shown to have various beneficial effects against inflammation and inflammatory diseases, as well as anti-tumour effects. Read more
Question. Tyrosine phosphorylation of signalling proteins at the plasma membrane controls essential actin-dependent processes in eukaryotes, including migration, adhesion, and communication. Read more
Joint Supervisors. Dr Harriet Walter, Department of Genetics, Genomics and Cancer Sciences and Dr Yolanda Markaki, Molecular & Cell Biology, University of Leicester. Read more
Project description. Lysosomes are the main degradative organelle in the cell. They contain >60 acid-hydrolases to digest cargo delivered via membrane trafficking processes including endocytosis and autophagy. Read more
Lysosomes are the main degradative organelle in the cell. They contain >60 acid hydrolases to digest cargo delivered via several membrane trafficking processes including endocytosis, phagocytosis and autophagy. Read more
Additional supervisor. Prof Thomas Otto (University of Glasgow). Background. Chronic kidney disease (CKD) is a major public health problem; it affects ~7% of the UK population and is a risk factor for cardiovascular disease and for end-stage kidney disease (ESRD), necessitating dialysis or transplantation. Read more
Leishmania parasites are responsible for causing a collection of devastating diseases affecting millions of people worldwide. They are spread via infected female sand flies, who feed on blood to produce eggs. Read more
This is an exciting opportunity for a 4-year DEBRA UK-funded PhD studentship within the Institute of Dentistry of Barts and The London Medical School and Dentistry at Queen Mary University of London (QMUL). Read more
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