BRCA1 and BRCA2 mutations predispose to both breast and ovarian cancers, with both factors playing many crucial roles in DNA damage repair and response. Read more
RNA Pol II (RNAPII) transcription and DNA replication are the two essential-for-life processes that use as a substrate the DNA in our cells, allowing the¬¬m to express the content of their genetic information and to propagate these instructions to daughter cells. Read more
ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions. Read more
University of Central Lancashire Funded Doctoral Training Centre for Industry Collaboration. Inaugural PhD Studentships. The successful applicant will receive an annual stipend payment of £16062 and tuition fees will be covered. Read more
Tumours evolve many ways to gain survival advantage. New blood vessels are formed to deliver extra oxygen, nutrients and to assist mobilisation of… Read more
There are two parallel studentships on offer. One (this project) is a wet lab project and the other is a bioinformatics project. Both are addressing the fact that multiple myeloma (MM) (a blood cancer of antibody producing cells) is nearly always diagnosed late. Read more
Replication stress, or replication-associated DNA damage, occurs frequently in cancer. There is a growing interest in targeting oncogene-induced replication stress for cancer therapy. Read more
TO APPLY, CLICK 'INSTITUTION WEBSITE'. Infant leukaemia is an aggressive malignancy with cure rates of less than 50%. Importantly, despite large international trials, there has been no improvement in survival over the last 2 decades. Read more
TO APPLY CLICK 'INSTITUTION WEBSITE' . The genetic landscape of mesothelioma is dominated by loss of function mutations in various tumour suppressor genes (eg. Read more
TO APPLY CLICK 'INSTITUTION WEBSITE' . Recent years have seen a revolution in our ability to generate high-resolution microscopic images of tumour tissue to reveal gene activity in single cells. Read more
TO APPLY CLICK 'INSTITUTION WEBSITE' . Colorectal cancer (CRC) remains the 2nd most common cancer and 3rd most common cause of cancer-related death globally. Read more
TO APPLY CLICK 'INSTITUTION WEBSITE' . γδ T cells are a rare population of T cell receptor-expressing cells that function like innate immune cells.γδ T cells consist of several different subtypes that can promote or prevent cancer progression, depending on the cytokines and cytotoxic molecules they express. Read more
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