This project is a collaboration between three research groups. Prof Skirmantas Kriaucionis research group aims to elucidate the molecular function of DNA modifications in normal cells, leading to the understanding of how defective pathways contribute to the neoplasia. Read more
The student will be supervised by two supervisors. Prof Skirmantas Kriaucionis research group aims to elucidate the molecular function of DNA modifications in normal cells, leading to the understanding of how defective pathways contribute to the neoplasia. Read more
This project is a collaboration between two research groups. Prof Skirmantas Kriaucionis research group aims to elucidate the molecular function of DNA modifications in normal cells, leading to the understanding of how defective pathways contribute to the neoplasia. Read more
Although cancers are highly mutated, it is factors above and beyond those mutations that allow a tumor to form. These factors include epigenetic gene programs embedded within the cell of origin (Baggiolini, et al, Science 2021). Read more
PHD finger protein 6 (PHF6) is a protein, consisting of two atypical plant homeodomains (aPHD1/2) with nuclear and nucleolar localization sequences. Read more
Acute Myeloid Leukaemia (AML) is a group of blood cancers, resulting from uncontrolled cellular proliferation of cells belonging to the myeloid lineage. Read more
Lead Institute / Faculty. Clinical and Experimental Sciences, Faculty of Medicine. Other members of the supervisory team. Professor Andrew J. Read more
Aggregation of aberrant proteins is a hallmark in age-related neurodegenerative diseases. These aggregates cause cell death and tissue degeneration leading to loss of function, hence strategies to reduce aggregation are necessary for delaying disease onset and progression. Read more
Heart failure has a serious impact on our society and once diagnosed has a poor survival rate. In the United Kingdom, there are about 1.5 million people living with the after-effects of a heart attack. Read more
The Oxford Interdisciplinary Bioscience Doctoral Training Partnership (DTP) programme is a 4-year DPhil*/PhD programme that aims to equip a new generation of researchers with the skills and knowledge needed to tackle the most important challenges in bioscience research. Read more
Brown adipose tissue is an enigmatic tissue that plays an important role in energy metabolism. The increasing prevalence of obesity-related disorders has led to a growing need for therapeutic strategies to reverse diet-induced weight gain. Read more
Mitochondrial inhibition is an important ‘OFF-target’ mechanism of drug-induced toxicity in the clinic, contributing to drug attrition in clinical trials and drug withdrawal following approval because of severe adverse events 1. Read more
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