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Endocrinology PhD Projects, Programs & Scholarships in the UK

We have 42 Endocrinology PhD Projects, Programs & Scholarships in the UK

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Showing 1 to 30 of 42
  Using CRISPR genome editing to determine the effects of obesity and hypertension associated polymorphisms
  Dr A MacKenzie, Prof M Delibegovic
Applications accepted all year round

Funding Type

PhD Type

Introduction. There is now little doubt that morbid conditions such as obesity, cardiovascular disease and diabetes are mechanistically linked.
  Central Nervous system Gene therapy to treat obesity Bardet-Biedl Syndrome (BBS). Analysis of the BBS brain development
  Dr V Hernandez
Applications accepted all year round

Funding Type

PhD Type

Bardet-Biedl syndrome (BBS) is a debilitating, often life-limiting heritable multisystem disorder caused by dysfunction of non-motile cilia (ciliopathy).
  Egr2 and 3 mediated T cell tolerance in cancer and their impact in immune checkpoint therapy
  Dr S Li
Applications accepted all year round

Funding Type

PhD Type

Tumour infiltrated lymphocytes (TILs) contain tumour reactive T cells and have been used as adoptive cell transfer therapy in patients which can mediate cancer regression.
  Telomere length elongation following treatment with chemotherapeutic drugs. Aim: To investigate the mechanisms which leads to telomere length elongation after treatment with tricostatin A and azacytidine.
  Dr T Roberts
Applications accepted all year round

Funding Type

PhD Type

Telomeres are specialised structures, which are present at the ends of chromosomes and serve to protect the chromosome from degradation during cell division.
  Exercise and nutritional status on metabolic factors, hormonal responses and inflammation in women
  Dr J Allgrove
Applications accepted all year round

Funding Type

PhD Type

Obesity is a major risk factor for chronic diseases such as type 2 diabetes, adverse cardiovascular events and metabolic syndrome-related disorders.
  Investigating metabolic changes in neurodegeneration
  Dr F Mackenzie, Dr M Stolinski
Applications accepted all year round

Funding Type

PhD Type

This 3-year PhD will study the increasingly recognised association between metabolic disease and neurodegeneration using in vitro cell culture methods.
  Role of telomere attrition in cardiometabolic disease risk
  Dr J Buxton, Dr N Hill
Applications accepted all year round

Funding Type

PhD Type

Common conditions such as Type 2 diabetes (T2D) and coronary artery disease (CAD) are complex disorders caused by a myriad of interacting genetic and lifestyle factors.
  The role of matrix interactions in regulating the SPARC family of matricellular proteins.
  Dr N Hill, Dr A Munasinghe
Applications accepted all year round

Funding Type

PhD Type

The SPARC family of matricellular proteins determine the way in which cells respond to their extracellular environment. SPARC family proteins interact with a range of binding partners, including matrix proteins (1).
  Metabolic programming: Role of micronutrient (B12) deficiency and associated epigenetic marks
  Dr A Antonysunil
Applications accepted all year round

Funding Type

PhD Type

The global epidemic of childhood obesity is a major public health issue. Although current adverse lifestyle (nutrition and physical inactivity) contributes to obesity, a growing body of evidence links early life nutritional adversity to the development of obesity and metabolic disorders in children.
  Seed dormancy and germination: understanding the molecular basis to improve seed quality and seedling performance of horticultural and agricultural crops
  Prof G Leubner
Applications accepted all year round

Funding Type

PhD Type

Plant seeds and fruits are at the beginning and the end of most important food supply chains that are central to human existence (food security).
  Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials
  Dr V Liu, Dr L Swanton
Applications accepted all year round

Funding Type

PhD Type

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function.
  Investigating the mechanisms contributing to placental dysfunction in pregnancies complicated by diabetes: role of the hexosamine biosynthetic pathway
  Prof M Westwood, Prof J Aplin, Dr J Myers
Applications accepted all year round

Funding Type

PhD Type

Maternal diabetes is a major risk factor for fetal overgrowth, which is associated with poor outcomes including stillbirth, neonatal morbidity and increased risk of diabetes in adulthood.
  Control of Parathyroid Hormone Secretion
  Dr D Ward, Dr J Bruce
Applications accepted all year round

Funding Type

PhD Type

The regulation of parathyroid hormone (PTH) secretion is of fundamental importance for calcium homeostasis and in mineral conditions affecting bone and the kidneys.
  Rhythmic control of energy balance - to understand how our internal clocks regulate energy metabolism
  Dr D Bechtold, Prof D Ray
Applications accepted all year round

Funding Type

PhD Type

24-hour rhythms are present in virtually all aspects of our behaviour and physiology. These rhythms are underpinned by circadian clocks that run throughout the body, and act within each tissue to orchestrate many organ functions and rhythmic activities (e.g.
  The effect of female sex hormones on hearing and tinnitus.
  Dr K Kluk
Applications accepted all year round

Funding Type

PhD Type

Sex hormones fluctuate in level in women, both during the lifespan and during the ovarian cycle. Recent research suggests that oestrogen is neuroprotective, and may affect auditory function.
  Computer-aided Detection of Osteoporotic Vertebral Fractures in Clinical Images Using Convolutional Neural Network Constrained Local Models (CNN-CLMs)
  Dr P Bromiley, Prof T Cootes, Dr EP Kariki
Applications accepted all year round

Funding Type

PhD Type

Osteoporosis is a common, degenerative skeletal disorder that increases the risk of fractures and causes significant morbidity and mortality.
  Is there a switch between prostamides and prostaglandins in women with dysmenorrhoea and heavy menstrual bleeding?
  Prof K Marshall, Dr D Fischer, Prof A Nicolaou
Applications accepted all year round

Funding Type

PhD Type

Dysmenorrhoea, painful menstrual cramps, and heavy menstrual bleeding are common debilitating symptoms in women with or without an underlying pelvic pathology.
  Adipose tissue functional responses to nutritional stress
  Dr K Manolopoulos, Prof D Calebiro
Applications accepted all year round

Funding Type

PhD Type

Obesity is the leading cause of insulin resistance and type 2 diabetes. Adipose tissue dysfunction has been proposed as being central in the pathophysiology of obesity-related complications.
  Determining the translational potential of the highly phosphorylated proto-oncogene PBF
  Dr V Smith
Applications accepted all year round

Funding Type

PhD Type

In order to translate the many molecular alterations now detectable in human tumours into effective clinical management we need to fully understand their impact on tumour biology.
  Development of novel artificial intelligence algorithms for network wide metabolic flux analysis with stable isotope tracers
  Dr C Ludwig, Dr S He
Applications accepted all year round

Funding Type

PhD Type

The efficient function of the metabolic network in eukaryotic cells relies on its separation into a number of closely-linked but metabolically distinct compartments.
  Identification of novel regulators of pancreatic beta-cell identity
  Dr I Akerman
Application Deadline: 31 October 2019

Funding Type

PhD Type

Diabetes is the largest epidemic in human history that affects 1 in 12 adults worldwide. Due to our modern lifestyle, it is one of the few diseases where the incidence is set to rise dramatically, with projections putting 650 million people at risk by 2040.
  Polo-like kinase inhibitors for targeted therapy in adrenocortical carcinoma
  Dr C L Ronchi, Dr P Foster
Applications accepted all year round

Funding Type

PhD Type

Adrenocortical carcinoma (ACC) is a rare cancer with a generally poor prognosis and partially unknown pathogenesis.
  Repairing DNA Damage in Response to BRAF Mutation
  Dr C McCabe, Prof G Stewart
Applications accepted all year round

Funding Type

PhD Type

We are the leading thyroid cancer research group in the UK; we work on other neoplasias as well, including breast and head and neck etc.
  Targeting steroid metabolism to block colorectal cancer proliferation
  Dr P Foster, Dr L Cox
Applications accepted all year round

Funding Type

PhD Type

Our group is a world leader in targeting specific aspects of steroid metabolism to block cancer growth. Our research has been instrumental in the successful pre-clinical and clinical development of various novel anti-cancer compounds.
  Targeting the Role of Myeloid Steroid Metabolism in Chronic Inflammation
  Dr R Hardy, Dr P Foster
Applications accepted all year round

Funding Type

PhD Type

Background. Myeloid derived cell populations such as macrophages play a critical role in the early innate immune response, whilst dendritic cells are essential in bridging the progression to an adaptive immune response.
  Vitamin D and immunometabolism
  Prof M Hewison, Dr S Dimeloe
Applications accepted all year round

Funding Type

PhD Type

Vitamin D has potent anti-inflammatory and antibacterial immune effects.
  Health Opportunity for Patient Empowerment in Gestational Diabetes (HOPE-GDM)
  Research Group: Chemistry and Biosciences
  Prof A M Graham, Prof R Qahwaji, Prof A Locke
Applications accepted all year round

Funding Type

PhD Type

Gestational Diabetes is a temporary condition diagnosed at 24-28 weeks gestation, where the body is unable to maintain normal blood glucose levels due to insulin resistance during pregnancy.
  Extracellular Matrix Abnormalities in Cardiac Insulin Resistance as a Therapeutic Target of Chronic Heart Failure
  Dr L Kang, Prof C Lang
Applications accepted all year round

Funding Type

PhD Type

Description. Diabetes and chronic heart failure (CHF) often coexist such that each condition may affect the other in terms of causation and outcome.
  Epidemiology of common endocrine disorders and diabetes
  Dr T Sathyapalan
Applications accepted all year round

Funding Type

PhD Type

A PhD project is available in Prof Sathyapalan group with a focus on the epidemiology of common endocrine disorders and diabetes at the University of Hull.
  Exploring the role of meiotic proteins in cancer
  Dr U McClurg
Applications accepted all year round

Funding Type

PhD Type

Cancer is one of the main causes of death worldwide. The main challenge is the development of treatments specifically targeting cancers without killing healthy cells.
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