Genetics PhD Projects, Programmes & Scholarships in the UK

We have 242 Genetics PhD Projects, Programmes & Scholarships in the UK

Self funded MSc by Research or PhD in Biology: Delineating neuronal structure and function in the autism spectrum disorder neurofibromatosis type 1

University of York Department of Biology

Neurofibromatosis type 1 (NF1) is among the most common monogenetic disorders of humans and patients show a high prevalence of Autism Spectrum Disorders. Read more

Supervisors: Dr I Hahn, Dr W Brackenbury

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Exploring the Ubiquitin-Proteasome system’s Impact on Ageing and Disease: The Interplay of Genetics, Lifestyle, and Environment

University of Reading Department of Biomedical Sciences

Project Overview. Unravelling the molecular and cellular mechanisms driving ageing to improve human health across the lifespan is a central aim of biomedical research. Read more

Supervisor: Dr E Kevei

Year round applications PhD Research Project Self-Funded PhD Students Only

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Microplastics and Nanoplastics as Emerging Risk Factors in Neurodevelopmental and Neurodegenerative Condition

University of Reading Department of Biomedical Sciences

Project Overview. Microplastics (MPs) and nanoplastics (NPs) are ubiquitous environmental pollutants raising concerns due to their potential adverse effects on human health. Read more

Supervisor: Dr E Kevei

Year round applications PhD Research Project Self-Funded PhD Students Only

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Exploring the interplay between ageing, gut microbiome, and neurodegenerative diseases

University of Reading Department of Biomedical Sciences

Project Overview. Neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease represent major health risks in ageing societies. Read more

Supervisor: Dr E Kevei

Year round applications PhD Research Project Self-Funded PhD Students Only

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SLS SF4: Identifying pro-longevity drug targets by finding how the nervous system controls aging

University of Westminster School of Life Sciences

Our ageing society is a critical issue. Remaining healthier for longer is a priority with the burden of age-related disease. We want to identify drug targets to develop pro-longevity pharmaceuticals that preserve cognitive function later in life. Read more

Supervisors: Dr FP Partridge , Dr A Barr, Dr AA Anagnostopoulou

17 May 2024 PhD Research Project Self-Funded PhD Students Only

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Investigating the metabolic link between leukaemia and heart failure (RUSHWORTHS_U24BIGC)

University of East Anglia Norwich Medical School

Primary supervisor - Dr Stuart Rushworth. Secondary supervisor - Dr James Smith. Rushworth Lab. This 4-year PhD project funded by the Big C cancer charity represents an exciting opportunity to develop and conduct research at the forefront of cancer research. Read more

Supervisor: Dr S Rushworth

7 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Self funded MSc by research or PhD in Biology: Chemical warfare in the rhizosphere: understanding the defensive role of plant root exudates against the bacterial pathogen Ralstonia solanacearum

University of York Department of Biology

Lead supervisor. Dr Andrea Harper. The student will be registered with the Department of Biology. R. solanacearum is a devastating bacterial plant pathogen that has a global distribution, wide host range, and no effective control methods. Read more

Supervisor: Dr A Harper

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Using nutrigenetic, nutrigenomic and machine learning approaches to investigate the risk of cardiometabolic disease-related traits in ethnically diverse populations.

University of Reading Department of Food and Nutritional Sciences

This PhD project represents an exciting opportunity to develop and conduct research at the forefront of nutritional and genetic epidemiology, contributing to the prediction, prevention, and better understanding of the development of non-communicable diseases such as obesity and diabetes, using datasets from multiple ethnic groups. Read more

Supervisor: Dr V Karani

Year round applications PhD Research Project Self-Funded PhD Students Only

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Exploring Molecular Pathways for Improved Neural Regeneration in Spinal Cord Injury

University of Portsmouth School of Pharmacy and Biomedical Sciences

In the UK, 50,000 people currently live with spinal cord injury (SCI), and an additional 2,500 new cases are reported annually. SCI results in a permanent loss of sensation and movement, serving as a primary cause of paralysis for which effective treatments are currently unavailable. Read more

Supervisors: Dr J Cayuso, Dr P Dey, Prof A Butt

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying variants impacting splicing of 5’ and 3’ UTRs and underpinning inherited retinal disease

The University of Manchester Faculty of Biology, Medicine and Health

Genomic variation that impacts splicing is well established as a cause of genomic disorders, but is almost exclusively limited to protein-coding exons and introns intersecting protein-coding exons. Read more

Supervisors: Dr J Ellingford, Prof R O'Keefe

15 June 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Investigating the impact of galectin-ligand interaction on cancer cell resistance to chemotherapeutic treatment

University of Liverpool Institute of Life Course and Medical Sciences

Galectins are multifunctional carbohydrate-binding proteins that are expressed by many types of human cells. Changes of galectin expression commonly occur in cancer (e.g. Read more

Supervisor: Prof LG Yu

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions

University of Liverpool Institute of Life Course and Medical Sciences

Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more

Supervisor: Dr VPV Pekovic-Vaughan

Year round applications PhD Research Project Self-Funded PhD Students Only

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Using pre-clinical models of disease to define new targets to slow joint degeneration in osteoarthritis

University of Liverpool Institute of Life Course and Medical Sciences

The main overall aim of this project is to understand mechanisms of joint degeneration during osteoarthritis progression in order to define new targets for therapy. Read more

Supervisor: Dr B Poulet

Year round applications PhD Research Project Self-Funded PhD Students Only

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MScR - In vivo characterisation of novel risk genes for Alzheimers disease identified by Genome Wide Association Studies

University of Bristol School of Physiology, Pharmacology & Neuroscience

Genome Wide Association Studies (GWAS) for Alzheimer’s disease (AD) have identified a number of genes that are significantly associated with the disease (van der Kant et al., 2019). Read more

Supervisor: Prof J Hodge

Year round applications PhD Research Project Self-Funded PhD Students Only

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Functional effects of variable number tandem repeat expansions in idiopathic pulmonary fibrosis

University of Leicester Department of Genetics and Genome Biology

Research Group: Human & Medical Genetics

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by the formation of scar tissue in the lungs. Read more

Supervisor: Prof E Hollox

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding the role of mucin genetic variation in lung disease

University of Leicester Department of Genetics and Genome Biology

Research Group: Human & Medical Genetics

Understanding how genetic variation contributes to lung diseases is important in understanding how the disease develops and identifying potential molecular targets for therapy. Read more

Supervisor: Prof E Hollox

Year round applications PhD Research Project Self-Funded PhD Students Only

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Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

University of Dundee School of Life Sciences

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

Supervisors: Prof G Sapkota, Dr S Virdee

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Investigating lysosomal (dys)function in ageing and neurodegeneration

University of Reading Department of Biomedical Sciences

Project Overview. Ageing is associated with a decline in the functions of an organism (López-Otín, C. et al. Cell, 2023) and correlates with an increased risk of developing diseases in the later life (Niccoli, T. Read more

Supervisors: Dr S Cogo, Dr E Kevei

Year round applications PhD Research Project Self-Funded PhD Students Only

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The Importance of Muscle Stem Cells: Implications for Muscle Repair in Inflammation and Trauma

University of Nottingham School of Medicine

Skeletal muscle possesses a remarkable capacity for adaptation and repair, processes essential in the maintenance of skeletal muscle health. Read more

Supervisors: Dr S Joanisse, Prof P Greenhaff, Dr JM Mallinson, Dr C Deane

30 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Determining the biological basis of observed clinical outcomes in juvenile idiopathic arthritis using genetics and multiomics

The University of Manchester Faculty of Biology, Medicine and Health

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory arthritis affecting children and young people with an age of disease onset less than 16 years of age. Read more

Supervisors: Dr J Bowes, Dr J Humphreys

Year round applications PhD Research Project Self-Funded PhD Students Only

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Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

University of Bristol Bristol Medical School

Genome wide association studies (GWAS) have discovered many genetic associations for traits and diseases. However, most GWAS signals reside in non-coding regions (outside genes), and it is likely that GWAS variants confer their effects through modulating regulatory mechanism. Read more

Supervisor: Dr J Min

Year round applications PhD Research Project Self-Funded PhD Students Only

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Endothelial glycocalyx damage as a therapeutic target in sepsis-associated Acute Kidney Injury

University of Bristol Bristol Medical School

Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific and supportive of the vital organ systems in the hope the kidney will recover. Read more

Supervisor: Prof S Satchell

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding the role of spliceosome gene mutations in disease

The University of Manchester Faculty of Biology, Medicine and Health

The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more

Supervisors: Prof R O'Keefe, Prof B Newman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Noise and Evolution in Ageing Cellular Power Stations

Imperial College London Department of Mathematics

PhD Project. Imperial College Mathematics. Student Background. Theoretical Physics, Mathematics/Statistics, Electrical Engineering, Computing (Biological knowledge not required). Read more

Supervisor: Prof N Jones

Year round applications PhD Research Project Competition Funded PhD Project (European/UK Students Only)

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Application of machine learning algorithms to medical images and clinical/DNA data

The University of Manchester Department of Electronic and Electrical Engineering

This project will develop an automated classifier or the estimation of prognosis of the illness using medical images of the human body, clinical data, and gene information. Read more

Supervisor: Dr F Costen

Year round applications PhD Research Project Self-Funded PhD Students Only

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Genomic and Proteomics-Based Characterisation of Microalgal Cell Factories

University of Sheffield Department of Chemical & Biological Engineering

Microalgae have generated increasing interest as microbial cell factories to produce proteins, pigments, therapeutics, and nutraceuticals. Read more

Supervisors: Dr J Pandhal, Prof MJ Dickman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Glycosylation in Microalgal Host Cells

University of Sheffield Department of Chemical & Biological Engineering

Microalgae have generated increasing interest as microbial cell factories to produce therapeutics proteins. This is because they can grow on very cheap media and their GRAS (generally regarded as safe) status means they are a fantastic option for the production of therapeutics that can be administered orally. Read more

Supervisors: Dr J Pandhal, Dr C Evans

Year round applications PhD Research Project Self-Funded PhD Students Only

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PhD studentship - Mitochondria and nuclear positioning in skeletal muscle

Newcastle University Translational and Clinical Research Institute

Award Summary. Tuition fees (paid at the home rate) and an annual stipend of £18,622 (2023/2024 rate), with support for research costs. Read more

Supervisor: Dr A Vincent

30 April 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Role of BTG1 and BTG2 in acute lymphocytic leukaemia and diffuse large B-cell lymphoma

University of Nottingham School of Pharmacy

Acute lymphocytic leukaemia (ALL) and diffuse large B-cell lymphoma (DLBCL) is often associated with small deletions of or point mutations in the highly related BTG1 or BTG2 genes. Read more

Supervisor: Dr G S Winkler

Year round applications PhD Research Project Self-Funded PhD Students Only

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