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Molecular Biology PhD Projects, Programs & Scholarships in the UK

We have 702 Molecular Biology PhD Projects, Programs & Scholarships in the UK

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Showing 421 to 450 of 702
  Investigating the remodelling of inhibitory brain circuits in early Alzheimer’s disease. PhD in Medical Studies (MRC GW4 BioMed DTP)
  Prof A Randall
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Professor Andrew Randall, Medical School, College of Medicine and Health, University of Exeter. Dr Jonathan Witton, College of Medicine and Health, University of Exeter.
  Neural circuit dysfunction in a mouse model of 22q11.2 deletion syndrome. PhD in Medical Studies (MRC GW4 BioMed DTP)
  Dr M Craig
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Dr Michael Craig, Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter.
  Regulation of food preference and reward by the brain. PhD in Medical School (MRC GW4 BioMed DTP)
  Dr K Ellacott
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Dr Kate Ellacott, Institute of Biomedical and Clinical Sciences, Medical School, University of Exeter. Prof Anthony Pickering, Pharmacology and Physiology, University of Bristol.
  The epigenetics of Parkinson’s disease: searching for novel drug targets. PhD in Medical Studies (MRC GW4 BioMed DTP)
  Dr A Migdalska-Richards
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Dr Anna Migdalska-Richards, Institute of Clinical Biosciences, College of Medicine and Health, University of Exeter.
  The influence of JAKMIP1, a key risk gene for autism, on neural circuit function. PhD in Medical Studies (MRC GW4 BioMed DTP)
  Dr A Oguro-Ando
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Dr Asami Oguro-Ando, The Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter.
  Understanding how altered GABA signalling in the brain’s master clock contributes to circadian rhythm disruption in Alzheimer’s disease. PhD in Medical Studies (MRC GW4 BioMed DTP)
  Dr M Belle
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Dr Mino Belle, Institute of Biomedical and Clinical Science, Medical School, University of Exeter. Dr James Hodge, Faculty of Life Sciences, University of Bristol.
  Biotic and abiotic factors influencing the epidemics of cassava viral diseases in Africa.
  Dr S Bouvaine
Application Deadline: 10 November 2019

Funding Type

PhD Type

Cassava mosaic begomoviruses (CMVs) (family Geminiviridae) and Cassava brown streak ipomoviruses (CBSIs) (family Potyviridae) are transmitted by whiteflies (Bemisia tabaci species complex) and are causing two of the worst diseases that constrain production of the important staple crop cassava.
  PhD studentship opportunity - Development of efficient aerosolization devices for formulated high viscosity inhalation products
  Prof D Murnane, Dr L Urbano
Application Deadline: 31 October 2019

Funding Type

PhD Type

The University invites applications to join our Hertfordshire Knowledge Exchange Partnership (HKEP) scheme, a 1-year industrial placement followed by a 3-year PhD studentship funded jointly by the European Regional Development Fund, Hertfordshire LEP and Merxin ltd.
  How does the vascular matrix environment influence platelet activation?
  Dr S Calaminus
Application Deadline: 31 March 2020

Funding Type

PhD Type

The platelet is a blood cell that plays a key role in the prevention of bleeding. For platelets to form a clot or thrombus effectively, they must rearrange their actin cytoskeleton to withstand high shear stress from blood flow in the arteries.
  Modulation of platelet-mediated innate immune responses in chronic lymphocytic leukaemia
  Dr M Arman
Application Deadline: 31 March 2020

Funding Type

PhD Type

Chronic lymphocytic leukaemia (CLL) is the most common form of leukaemia in the Western World. B-cell receptor-induced intracellular signals are critical for the survival of leukaemia cells and disruption of this pathway by the Bruton’s tyrosine kinase (Btk) inhibitor ibrutinib is a highly effective CLL therapy.
  Precision-cut lung slices to investigate the effect of human rhinovirus on cough and airway inflammation
  Dr L Sadofsky
Application Deadline: 31 March 2020

Funding Type

PhD Type

The human Rhinovirus (RV) is the major cause of the common cold. There are no current treatments or vaccines for the virus other than over the counter preparations to alleviate symptoms.
  Re-purposing diabetes medicines to manage bleeding complications in myeloproliferative neoplasms.
  Prof Tim Palmer, Dr D Allsup
Application Deadline: 31 March 2020

Funding Type

PhD Type

Myeloproliferative neoplasms (MPNs) are a group of three related blood cancers in which the bone marrow overproduces one of the three cellular components of blood (erythrocytes, leukocytes and platelets).
  Targeting chronic inflammation to improve vein graft function following bypass surgery.
  Prof Tim Palmer, Prof M Loubani
Applications accepted all year round

Funding Type

PhD Type

Targeting chronic inflammation to improve vein graft function following bypass surgery. Coronary heart disease (CHD) causes over 66,000 deaths/year in the UK.
  The Role of CCR5 in Embryo Development
  Dr R Sturmey
Applications accepted all year round

Funding Type

PhD Type

Chemokines are small peptides that play key roles in cell migration and signalling. They act primarily by binding specific cell surface receptors to drive intracellular signalling and are key mediators of the immune response.
  An integrated approach to the study of cellular interactions with amyloid
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E W Hewitt, Prof S E Radford
Applications accepted all year round

Funding Type

PhD Type

The formation of insoluble amyloid fibrils is associated with a spectrum of human disorders, the amyloidoses, which include Alzheimer’s, Parkinson’s, type 2 diabetes and dialysis related amyloidosis (DRA).
  Dissecting the molecular mechanisms of antibiotic resistance in bacterial pathogens
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A O'Neill
Applications accepted all year round

Funding Type

PhD Type

Antibiotics make possible the treatment and cure of life-threatening bacterial infections. Since their introduction in the middle years of the 20th Century, they have added ~10 years to the human lifespan, and have become a cornerstone of modern medicine.
  Mathematical Virology: A New Mathematical Approach to Viral Evolution Grounded in Experiment
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

Mathematical modelling of natural phenomena has the potential to be predictive but requires direct verification by experiment. Such models can then be very powerful indicators of our understanding and they permit in silico simulations of situations that are difficult to test experimentally.
  Synthetic Virology: Development of gene delivery vectors/synthetic vaccines
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

There is worldwide interest in exploiting our modern understanding of genomics to target gene expression therapeutically via a variety of mechanisms, such as transgene insertion and CRISPR-Cas gene editing.
  Towards new antibacterial drugs to treat infections caused by multidrug-resistant bacteria: identification and characterization of novel natural product antibiotics
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A O'Neill
Applications accepted all year round

Funding Type

PhD Type

The World Health Organization (WHO) has declared antimicrobial drug resistance one of the greatest problems currently facing human health, and the situation is especially grave in the case of infections caused by bacterial pathogens.
  Sociobiology on the fly; understanding social interactions in multispecies groups
  Research Group: School of Biology
  Dr A Bretman, Dr X Harrison
Application Deadline: 6 January 2020

Funding Type

PhD Type

The effects of social environments on individuals are widespread, even in species not classically thought of as social (Bailey and Moore 2018).
  Development and characterisation of synthetic ion channel binding proteins.
  Research Group: School of Biomedical Sciences
  Dr J D Lippiat, Dr D Tomlinson
Applications accepted all year round

Funding Type

PhD Type

We are developing methods to identify novel proteins, Affimers, that recognise extracellular domains of ion channels. These have applications in various aspects of biology, from tools to visualise the location and distribution of ion channels in native tissue, to novel modulators of ion channel function.
  Structural and Biophysical Characterisation of Novel Membrane Protein Ion Channels (Chinese candidates / China mainland only)
  Research Group: School of Biomedical Sciences
  Dr C Pliotas
Application Deadline: 8 January 2020

Funding Type

PhD Type

Research in the Pliotas group (https://www.pliotasgroup.org/) focuses on the investigation of molecular mechanisms which underlie the structure and function of integral membrane proteins, in particular ion channels.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Applications accepted all year round

Funding Type

PhD Type

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  Epigenetics and Cancer: Development of Novel Tools to Determine how Aberrant V(D)J Recombination Reactions Cause Leukaemia
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Applications accepted all year round

Funding Type

PhD Type

V(D)J recombination generates a highly diverse set of immunoglobulin and T cell receptor genes to enable vertebrates to fight a vast range of infections.
  Defining a novel assembly pathway in ssRNA viruses using X-ray footprinting.
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

Project co-supervised by Prof. Peter Stockley at Leeds and Prof. Reidun Twarock at University of York, as part of the White Rose network "Structural and Mechanistic Biology at the RNA/Ligand Interface".
  Genomic basis of extra-group paternity in the cooperatively breeding Seychelles warbler
  Dr H L Dugdale
Applications accepted all year round

Funding Type

PhD Type

Indirect genetic benefits are hypothesised to drive the evolution of extra-group paternity (EGP), yet its genomic basis is unknown.
  Developing pluripotent stem cell models of inherited retinal diseases
  Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Background. Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide.
  Enhancing Oncolytic Virus-induced Immunotherapy using Eicosapentaenoic Acid (EPA)
  Dr F Errington-Mais, Dr MA Volpato
Applications accepted all year round

Funding Type

PhD Type

Breast cancer is the most commonly diagnosed cancer in women with triple-negative breast cancer (TNBC) having the worst prognosis, highest death rate and lowest overall survival.
  Epigenetic therapy using ultrasound-mediated microbubble drug delivery for cancer treatment
  Dr E Valleley, Dr L Coletta
Applications accepted all year round

Funding Type

PhD Type

The project is an interdisciplinary, pre-clinical study that aims to investigate the response of human tumour cells to treatment with epigenetic inhibitors (such as DNA methyltransferase inhibitors), as a potential combination therapy for colorectal cancer (CRC).
  Exploring the mitotic functions of ASPM in human brain size regulation
  Dr J Bond, Dr E E Morrison, Prof M Peckham
Applications accepted all year round

Funding Type

PhD Type

The increase in relative brain size is one of the most striking events in human evolution. To determine how human brain size is normally regulated we have investigated the cause of autosomal recessive primary microcephaly (MCPH), a congenital disorder of reduced brain size and associated mental retardation.
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