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Pathology PhD Projects, Programs & Scholarships in the UK

We have 53 Pathology PhD Projects, Programs & Scholarships in the UK

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Showing 1 to 30 of 53
  Budding yeast as a model for sudden cardiac death
  Dr T Hoefken
Applications accepted all year round

Funding Type

PhD Type

Sudden unexpected cardiac death is responsible for about half of all heart disease deaths. It is an unexpected death caused by a change in heart rhythm.
  Could anti-inflammatory treatment at ACL reconstruction improve biological, functional and clinical outcomes?
  Dr D Mason, Prof C A Holt
Application Deadline: 14 November 2019

Funding Type

PhD Type

This project will test the hypothesis that inflammation after ACL reconstruction surgery is detectable in the joint fluids and blood, and reduces joint function and surgical outcomes; and that anti-inflammatory medication reduces inflammation and improves joint function and surgical outcomes.
  Biomechanics of orthotic treatment for hand pathology
  Dr A Kedgley
Application Deadline: 1 October 2019

Funding Type

PhD Type

Applications are invited for a 4-year PhD studentship in the biomechanics of orthotic treatment for hand pathology, within the group headed by Dr Angela Kedgley (http://www.kedgley.org), to be carried out within the Department of Bioengineering at Imperial College London.
  Curing Genetic Muscle diseases
  Dr J Ochala
Applications accepted all year round

Funding Type

PhD Type

Congenital myopathies are a group of genetic muscle diseases with unclear mechanisms and no efficient treatment.
  Understanding the cytoskeletal and biophysical changes associated with fibroblast activation during scar formation
  Dr B Stramer, Dr T Shaw
Applications accepted all year round

Funding Type

PhD Type

A PhD studentship is available to work in the laboratory of Dr. Brian Stramer (https://www.kcl.ac.uk/lsm/research/divisions/randall/research/sections/motility/stramer/index) in the Randall Centre for Cell and Molecular Biophysics, King’s College London.
  Potential therapeutic effects of natural products in Human Papillomavirus (HPV) related cervical cancers
  Dr H Ashrafi
Applications accepted all year round

Funding Type

PhD Type

Cervical cancer is one of the most common types of cancer affecting women worldwide. Infection caused by high-risk human papillomaviruses (HPVs), especially type 16 and 18 are implicated in the etiology of most cervical cancers.
  The role of matrix interactions in regulating the SPARC family of matricellular proteins.
  Dr N Hill, Dr A Munasinghe
Applications accepted all year round

Funding Type

PhD Type

The SPARC family of matricellular proteins determine the way in which cells respond to their extracellular environment. SPARC family proteins interact with a range of binding partners, including matrix proteins (1).
  Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials
  Dr V Liu, Dr L Swanton
Applications accepted all year round

Funding Type

PhD Type

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function.
  Epigenetic regulation in heart failure and cardiac sudden death
  Dr X Wang, Dr V Liu
Applications accepted all year round

Funding Type

PhD Type

A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem.
  Insights into eye disease: understanding the molecular basis of age-related macular degeneration
  Prof T Day, Dr S Clark
Applications accepted all year round

Funding Type

PhD Type

Dysregulation of innate immunity has been implicated as playing a key role in the development of age-related macular degeneration (AMD) – a major form of blindness in the industrialised world (see [1-5]).
  Adaptation to oxidative stress in hepatitis C virus persistence: the role of IRES-dependent translation.
  Dr S-W Chan, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

Hepatitis C virus (HCV) causes a clinically important disease affecting 3% of the world population (Chan 2014). About 75% of the infection will develop into chronic hepatitis, which can then progress into fibrosis, cirrhosis and hepatocellular carcinoma.
  Basal stem cells in the lung and their recognition of dying cells
  Prof T Hussell, Dr N Fujino
Applications accepted all year round

Funding Type

PhD Type

Stem cell division and differentiation is critical for barrier repair following inflammation, but the initial trigger for this process is unknown.
  Virus pathogenesis: interplay between the unfolded protein response and innate immunity.
  Dr S-W Chan, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

The unfolded protein response (UPR) is a cellular homeostatic response in restoring endoplasmic reticulum balance upon stress conditions e.g.
  The impact of zinc deficiency on Alzheimer’s disease
  Dr C Lawrence, Dr D Brough
Applications accepted all year round

Funding Type

PhD Type

In addition to memory problems, people with Alzheimer’s disease (AD) also experience ‘non-memory’ behavioural symptoms including depression, anxiety, and agitation.
  Using zebrafish models to investigate cerebral arteriovenous malformations
  Dr P Kasher, Prof S Allan, Dr A Parry-Jones, Dr H Patel
Applications accepted all year round

Funding Type

PhD Type

Cerebral Arteriovenous Malformations (cAVM) relate to a spectrum of conditions associated with blood vessel abnormalities of the brain [1].
  Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
  Dr M Harte, Prof J Neill
Applications accepted all year round

Funding Type

PhD Type

Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist.
  Investigating the role of bioactive lipids in skin health
  Prof A Nicolaou, Prof C A O'Neill
Applications accepted all year round

Funding Type

PhD Type

Human skin depends on systemic provision of fatty acids that are important to maintain the integrity of the epidermal barrier as well as to support the associated immune and inflammatory reactions.
  How do phosphodiesterases contribute to the pathophysiology of heart failure?
  Prof A Trafford, Dr K Dibb
Applications accepted all year round

Funding Type

PhD Type

Heart failure (HF) remains a major cause of death with worse 5-year survival than all forms of cancer combined. This project seeks to understand the mechanisms that underlie two important contributing factors to death in HF patients; i) contractile failure and, ii) the increased propensity for arrhythmias.
  Creating “super” regulatory T cells to combat rejection, GVHD and autoimmunity through retroviral gene manipulation
  Dr N Jones, Dr S Lee
Applications accepted all year round

Funding Type

PhD Type

Research interests/description of main research theme. Foxp3+CD25+CD4+ regulatory T cells (Treg) have been shown to be essential for the induction of tolerance to foreign organ transplants in experimental models.
  Targeting the Role of Myeloid Steroid Metabolism in Chronic Inflammation
  Dr R Hardy, Dr P Foster
Applications accepted all year round

Funding Type

PhD Type

Background. Myeloid derived cell populations such as macrophages play a critical role in the early innate immune response, whilst dendritic cells are essential in bridging the progression to an adaptive immune response.
  Electrophysiological changes in ion channels in human haploid and diploid (spermatozoa and lymphocytes) after nanoparticle exposure
  Research Group: Chemistry and Biosciences
  Dr L Shang, Dr M H Brinkworth, Prof D Anderson
Applications accepted all year round

Funding Type

PhD Type

Nanomaterial-mediated delivery represents a promising technique for repro- and geno- toxicology with a potential to improve the safety and efficacy of existing methodologies, including experimental gene therapy and sperm-mediated gene transfer.
  Exploring aberrant inflammasome activation in chronic granulomatous disease
  Dr S Webster, Prof C E Bryant
Applications accepted all year round

Funding Type

PhD Type

This project will test the hypothesis. Aberrant inflammasome activation can be caused by mitochondrial ROS mediated NLRP3 inflammasome activation.
  Neutrophils and Chemokine Signalling in the Tumour Immune Micro-environment and Progression
  Dr T Iwata
Applications accepted all year round

Funding Type

PhD Type

Checkpoint inhibitor immunotherapy is promising, however still requires an improvement in response and development of markers to predict the patients who would benefit from this therapy.
  An integrated approach to the study of cellular interactions with amyloid
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E W Hewitt, Prof S E Radford
Applications accepted all year round

Funding Type

PhD Type

The formation of insoluble amyloid fibrils is associated with a spectrum of human disorders, the amyloidoses, which include Alzheimer’s, Parkinson’s, type 2 diabetes and dialysis related amyloidosis (DRA).
  Gastroesophageal reflux in respiratory disease: pathogenic role and improved management
  Prof L Houghton
Applications accepted all year round

Funding Type

PhD Type

Gastroesophageal reflux (GER) is associated with many lung diseases, including but not limited to idiopathic pulmonary fibrosis (IPF), non-IPF interstitial lung disease (ILD), chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), non-CF bronchiectasis, asthma and idiopathic chronic cough.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  How human teeth form and how that process fails in the inherited condition amelogenesis imperfecta
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Amelogenesis is the process of enamel formation and is essential for the development of functional teeth. Amelogenesis imperfecta (AI) is a failure of that process.
  Identification and functional characterisation of BRIT1/MCPH1 synthetic lethal genes to treat breast and ovarian cancer
  Dr S Bell, Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Women who have undergone surgery for breast and ovarian cancer often have additional chemotherapy to kill residual cancer cells and prevent recurrence.
  Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
  Dr S Papa
Applications accepted all year round

Funding Type

PhD Type

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow.
  The functional characterization of the tumour suppressor gene CSMD1 in breast cancer
  Dr S Bell
Applications accepted all year round

Funding Type

PhD Type

CUB and Sushi multiple domains protein 1 (CSMD1) maps to 8p23, a region deleted in many cancers including breast cancer. Our previous work has established that CSMD1 is an independent prognostic marker in ductal breast cancer, with reduced expression associated with high tumour grade and poor survival1.
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