We invite applications for a fully funded four-year EN & MN Lindsay Endowed PhD studentship in developing in silico approaches for compound optimisation in drug discovery at the University of Dundee, United Kingdom. Read more
The cellular quality-control process of mitophagy, entailing selective degradation of defective mitochondria (following damage to their DNA) by the process of autophagy, has attracted considerable research interest. Read more
The. Centre for Sustainable & Circular Technologies. at the University of Bath is inviting applications for the following funded PhD project commencing in October 2022. Read more
Fragment-Based Lead Generation of Small Molecule Inhibitors of the Nsp3 Macrodomain in SARS-CoV-2 – Towards New Antivirals for the Treatment of COVID-19. Read more
Cyclic ethers and amines are ubiquitous in biologically active natural and non-natural products. However, despite this prevalence and importance, there is no strategy for their asymmetric synthesis which is independent of heteroatom and/or ring size. Read more
Antibiotic-resistant pathogens are a huge threat in healthcare. The last resorts of conventional antibiotic drugs are unable to treat multi-resistant strains in patients. Read more
Blade spray mass spectrometry is a new and exciting development to characterise molecules rapidly, and accurately, at very low (sub parts per billion) levels in complex matrices. Read more
Cytosolic drug metabolising enzymes such as aldehyde oxidase play a pivotal role in metabolism of drugs. However, research into cytosolic enzymes has been relatively neglected in comparison with membrane bound enzymes such as cytochrome P450 (CYP) and uridine 5’-glucuronosyltransferases (UGTs). Read more
The Arseniyadis group (. https://arseniyadislab.sbcs.qmul.ac.uk/). is principally interested in the discovery and development of new synthetic methods which allow atom, step and redox-economy while providing high structural and functional complexity as well as stereocontrol. Read more
The Arseniyadis group (. https://arseniyadislab.sbcs.qmul.ac.uk/). is principally interested in the discovery and development of new synthetic methods which allow atom, step and redox-economy while providing high structural and functional complexity as well as stereocontrol. Read more
In 1987 the Montreal Protocol defined a pathway to eliminate the compounds proven to be harmful for the ozone, such as chlorofluorocarbon (CFC) employed as propellants in pressurised metered dose inhalers (pMDIs). Read more
The Project. In developing a new therapeutic agent, there are two questions to address. how to get the potential drug to the specific site in the body where it is needed and second, does it do what we want it to do at the target site and without undesirable side effects. Read more
The Project. Saturated oxygen and nitrogen containing heterocycles are widespread across natural products and pharmaceutically active ingredients. Read more
Osteoarthritis (OA) is caused by degradation of cartilage and accompanying structural changes to surrounding tissues in the articulating joints. Read more
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