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Pharmacology / Toxicology PhD Projects, Programs & Scholarships in the UK

We have 98 Pharmacology / Toxicology PhD Projects, Programs & Scholarships in the UK

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We have 98 Pharmacology / Toxicology PhD Projects, Programs & Scholarships in the UK

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Exploring the Molecular Architecture of FADD:Caspase-8 Signalling Platforms and how this determines cell fate

 Following exposure to drugs or environmental agents, several large multi-protein signalling platforms play a key role in determining cell death or survival. Caspase-8, a key regulator of cell fate, is recruited/activated within these complexes; for example, the Death-Inducing Signalling Complex (DISC), Necrosome and Ripoptosome. Read more

Exploring the Molecular Mechanism of Novel Mitochondrial Neurotoxins identified through a Machine Learning Approach

Mitochondrial inhibition is an important ‘OFF-target’ mechanism of drug-induced toxicity in the clinic, contributing to drug attrition in clinical trials and drug withdrawal following approval because of severe adverse events (Will & Dykens, 2014). Read more

Nanometer scale mapping as a tool to analyse adverse outcome pathways

Super-resolution fluorescence microscopy has revolutionized the understanding of cellular organization by allowing quantitative analysis of protein assemblies architecture, in situ, at the nanoscale (Sydor et al. Read more

Characterization of novel airway in vitro models for discovery toxicology

The cellular and molecular mechanisms of human lung development are only recently beginning to emerge. This knowledge gap has been mainly determined by the paucity of ex vivo material for research studies and the lack of adequate animal models recapitulating human lung development (Nikolic et al. Read more

The mechanism, function, and medically-relevant dysfunction of mitochondrial complex I (NADH:ubiquinone oxidoreductase)

Complex I (NADH:ubiquinone oxidoreductase) catalyses the first step in the respiratory chain and oxidative phosphorylation. NADH oxidation and quinone reduction, coupled to proton translocation across the inner membrane. Read more

The mechanism, function, and medically-relevant dysfunction of mitochondrial complex I (NADH:ubiquinone oxidoreductase)

Complex I (NADH:ubiquinone oxidoreductase) catalyses the first step in the respiratory chain and oxidative phosphorylation. NADH oxidation and quinone reduction, coupled to proton translocation across the inner membrane. Read more

4 Year Fully-Funded PhD Opportunities in Bioscience and Biotechnology

World-class PhD opportunities in Frontiers Bioscience, Bioscience for Sustainable Agriculture and Food, Bioscience for an Integrated Understanding of Health and Bioscience for Renewable Resources and Clean Growth. Read more

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