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Structural Biology PhD Projects, Programmes & Scholarships in the UK
We have 97 Structural Biology PhD Projects, Programmes & Scholarships in the UK
We have 97 Structural Biology PhD Projects, Programmes & Scholarships in the UK
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Overcoming replication stress–defining new mechanism from archaea to human
How cells respond to DNA replication stresses (e.g., DNA replication collapse, stalling or hyper-activity) is critical for their survival, and is a hallmark of cancers. Read more
Using antibodies as templates to develop small molecule anti-complement drugs to deliver to Alzheimer’s brain.
The School of Medicine, Dementia Research Institute (DRI) at Cardiff University is delighted to offer a full time three years funded Alzheimer's Society Studentship starting on 3rd October 2022. Read more
Role of APC/C subunit post-translational modifications on the function of the APC/C in mitosis
The APC/C is a large macromolecular E3 ubiquitin ligase, that, through targeting protein substrates for polyubiquitylation and 26S proteasome-mediated degradation coordinates the progression of cells through mitosis (1, 2). Read more
In situ HDX-MS of membrane protein-ligand interactions
The project aims to develop an HDX-MS workflow to profile ligand-membrane protein interactions. The identification of hits with high selectivity constitutes an important landmark for the design and development of novel therapeutics. Read more
Using structural biology to develop drugs and improve genetic testing for polycystic kidney disease
Are you looking for a PhD in structural and computational biology applied to drug development for human diseases?. Read more
Structure and function of Batten disease proteins
The neuronal ceroid lipofucscinoses are a group of inherited neurodegenerative disorders with primarily childhood onset. The most common form, also known as Batten disease or CLN3 disease, is caused by recessively inherited mutation in the CLN3 gene. Read more
mRNA epigenetics: Charaterization of a novel layer of gene regulation for essential brain functions
Research Group:
BBSRC MIBTP
For over 40 years we know about modified nucleotides in mRNA, but the functions for these essential modifications are largely elusive. Read more
Elucidating the mechanisms of outer membrane biogenesis in Gram-negative bacteria
The emergence of bacteria that are resistant to available antibiotics represents an enormous and growing global threat requiring new targets and strategies to combat infection. Read more
BeAST: Bio-electrochemical Applications for Sustainable Technologies
Use of fossil fuels by humans has littered the planet and increased greenhouse gas emissions in the air leading to a Climate Emergency. Read more
In silico glycosylation of AlphaFold protein structural models.
Background. The recent release of the AlphaFold Protein Structure Database by DeepMind and EMBL-EBI has made available to the scientific community highly accurate structural predictions for 20,000 human proteins and those from 20 other biologically relevant organisms. Read more
Engineering Enzymes for Organic Synthesis
Engineering Enzymes for Organic Synthesis. Professor Gideon Grogan, Department of Chemistry, University of York. Background. Our research group is interested in the identification and characterisation of enzymes and their application to organic synthesis. Read more
Identification and characterisation of novel flavivirus protease cleavages sites in mammalian and insect cells using N-terminomics
Positive sense single stranded RNA viruses translate their large open reading frames as a polyprotein that is cleaved by viral and/or host proteases to release mature viral proteins. Read more
Protein degradation-based gene therapies for neurodegenerative disease
Proteins fold like origami into complex three-dimensional shapes. This process can malfunction and result in misfolded proteins that stick together to form large aggregates. Read more
Structural and biological characterisation of virulence factor in Gram-negative pathogens affecting aquaculture
Gram-negative pathogens are responsible for major disease problems in humans and animals, and a better understanding of the mechanisms for how these bacteria cause infections is key to identifying more effective ways to prevent and treat outbreaks. Read more
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Ultrastructural insights into avian herpesvirus-host cell interactions
Marek’s disease virus (MDV) is a major avian alphaherpesvirus associated with Marek’s disease (MD) in poultry characterised by rapid-onset T-cell lymphomas, immunosuppression and paralysis causing annual economic losses of around $2 billion worldwide. Read more