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We have 90 Structural Biology PhD Projects, Programmes & Scholarships in the UK
Structural Biology PhD Projects, Programmes & Scholarships in the UK
We have 90 Structural Biology PhD Projects, Programmes & Scholarships in the UK
Maternal anxiety and language delays in children – both outcomes of the same epigenetic alteration?
Summary. Maternal depression and anxiety are highly common in pregnancy and associated with a negative effect on the child’s social and language skills. Read more
GW4 BioMed2 MRC DTP PhD project: Tackling Antimicrobial Resistance with Targeted Covalent Macrocycles
This project is one of a number that are in competition for funding from the GW4 BioMed2 MRC Doctoral Training Partnership which is offering up to 21 studentships for entry in September 2025. Read more
Supra-molecular architecture of neurotransmitter receptor complexes
Chemical synapses are cellular connectors that define the organization and function of neuronal circuits and, as a result, the fundamental ability of the brain to acquire, process and store information. Read more
Mechanism of transcription-coupled splicing
The production of messenger RNA in eukaryotic cells involves precursor mRNA (pre-mRNA) synthesis and processing. During splicing, the spliceosome removes noncoding introns from pre-mRNA in a co-transcriptional manner on the surface of RNA polymerase II (Pol II). Read more
Structures and mechanisms of the human replisome
Accurate genome duplication is essential for all forms of life. The molecular machinery that orchestrates this process is collectively termed the replisome. Read more
Cryo-EM structures of GPCRs from pathogenic fungi
Pathogenic fungi are responsible for about 1.5 million deaths worldwide per annum and fungi also cause the spoilage of about 25% of the world’s crops. Read more
Pathological protein assembly in neurodegenerative diseases
Neurodegenerative diseases are one of the greatest health challenges facing our society. This large group of diseases is characterised by the pathological assembly of specific proteins into filaments in the central nervous system. Read more
Cell biology underlying tuberculosis pathogenesis and drug resistance
TB remains the world’s greatest infectious killer despite a vaccine (BCG) for a century and effective antibiotics for 60 years. TB’s persistence over millennia in the face of major medical advances underscores the ability of Mycobacterium tuberculosis to evade and exploit host defences and antibiotics. Read more
Mechanistic insight into macromolecular machines
Large multiprotein complexes perform many essential functions in eukaryotic cells. My lab purifies, assays and determines structures of these macromolecular machines to understand their mechanisms. Read more
Biochemical and structural studies of yeast telomerase complexes
The ends of linear eukaryotic chromosomes are typically composed of tandem G-rich repeats, which play a crucial role in attracting telomeric protein factors to assemble large nucleoprotein structures known as telomeres. Read more
Structure and signalling of AMPA glutamate receptors in synaptic plasticity
Information transfer in the brain occurs at synapses, where memories are stored as a result of synaptic plasticity processes. AMPA-type glutamate-receptors (AMPA-Rs) ion channels, are the main mediators of signal transmission, and centrally contribute to synaptic plasticity. Read more
Developing fast machine learning potentials for the simulation of biomolecules
To date, most molecular dynamics simulations of biomolecules such as proteins have used molecular mechanics force fields. These are fast but limited in accuracy and do not allow chemical reactions, meaning they cannot be used to study processes such as enzyme catalysis. Read more
Cryo-EM studies of amyloids in neurodegenerative diseases
Abnormal filamentous inclusions of the proteins amyloid-beta, tau and alpha-synuclein characterise multiple human neurodegenerative diseases, which are called beta-amyloidoses, tauopathies and synucleinopathies, respectively. Read more
Cryo-EM study of the human kinetochore
Our research is focused on understanding the mechanisms and regulation of chromosome segregation in mitosis. During the cell cycle, accurate chromosome segregation ensures that both daughter cells inherit the correct complement of chromosomes. Read more
Discovering the “missing” transcription mechanisms
The complexity of eukaryotic life forms is driven by RNA polymerase II (Pol II), which transcribes all protein-coding genes and thousands of non-coding RNA loci. Read more