How cells respond to DNA replication stresses (e.g., DNA replication collapse, stalling or hyper-activity) is critical for their survival, and is a hallmark of cancers. Read more
The School of Medicine, Dementia Research Institute (DRI) at Cardiff University is delighted to offer a full time three years funded Alzheimer's Society Studentship starting on 3rd October 2022. Read more
The APC/C is a large macromolecular E3 ubiquitin ligase, that, through targeting protein substrates for polyubiquitylation and 26S proteasome-mediated degradation coordinates the progression of cells through mitosis (1, 2). Read more
The project aims to develop an HDX-MS workflow to profile ligand-membrane protein interactions. The identification of hits with high selectivity constitutes an important landmark for the design and development of novel therapeutics. Read more
The neuronal ceroid lipofucscinoses are a group of inherited neurodegenerative disorders with primarily childhood onset. The most common form, also known as Batten disease or CLN3 disease, is caused by recessively inherited mutation in the CLN3 gene. Read more
The emergence of bacteria that are resistant to available antibiotics represents an enormous and growing global threat requiring new targets and strategies to combat infection. Read more
Background. The recent release of the AlphaFold Protein Structure Database by DeepMind and EMBL-EBI has made available to the scientific community highly accurate structural predictions for 20,000 human proteins and those from 20 other biologically relevant organisms. Read more
Engineering Enzymes for Organic Synthesis. Professor Gideon Grogan, Department of Chemistry, University of York. Background. Our research group is interested in the identification and characterisation of enzymes and their application to organic synthesis. Read more
Positive sense single stranded RNA viruses translate their large open reading frames as a polyprotein that is cleaved by viral and/or host proteases to release mature viral proteins. Read more
Proteins fold like origami into complex three-dimensional shapes. This process can malfunction and result in misfolded proteins that stick together to form large aggregates. Read more
Gram-negative pathogens are responsible for major disease problems in humans and animals, and a better understanding of the mechanisms for how these bacteria cause infections is key to identifying more effective ways to prevent and treat outbreaks. Read more
Marek’s disease virus (MDV) is a major avian alphaherpesvirus associated with Marek’s disease (MD) in poultry characterised by rapid-onset T-cell lymphomas, immunosuppression and paralysis causing annual economic losses of around $2 billion worldwide. Read more
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