Commercial partner: . Cerevance. The student will be involved in an exciting multidisciplinary project aimed at determining the structural and molecular mechanisms of a range of novel inhibitors of the THIK1 K2P K+ channel. Read more
Chromatin regulators are a group of proteins that control the way the rest of the genome is opened up and “read” by the cellular machinery, with fundamental roles in development and disease. Read more
Lay summary. Proteins can be thought of as molecular machines that carry out work within cells. Protein activity can be regulated through the reversible attachment of certain chemical groups to specific amino acids within proteins. Read more
Pioneering discoveries from the Ciulli Laboratory have contributed to the establishment of a new modality of chemical intervention into biological systems. Read more
Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. Read more
SUMO has diverse roles in cellular physiology that in most cases are mediated by its ability to interact non-covalently with hydrophobic patches of low sequence complexity known as SUMO Interaction Motifs (SIMs). Read more
Ubiquitin signalling, which involves the posttranslational modification (PTM) of proteins with ubiquitin, regulates almost every aspect of eukaryotic biology. Read more
Recent advances from the Ciulli Lab and others have contributed to the establishment of a game-changing new modality of chemical intervention into biological system – one that moves beyond the state-of-the-art. Read more
ADP-ribosylation is a fundamental posttranslational modification where ADP-ribose is linked on to target proteins by ADP-ribose transferases and removed by the ADP-ribose hydrolases. Read more
This project aims to introduce a novel approach in studying blood flow in deformable vessels by simultaneously considering both the fluid (blood) and the structure (vessel) through analytical and numerical approaches. Read more
Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more
Summary. Maternal depression and anxiety are highly common in pregnancy and associated with a negative effect on the child’s social and language skills. Read more
About the GW4 BioMed2 Doctoral Training Partnership. The partnership brings together the Universities of Bath, Bristol, Cardiff (lead) and Exeter to develop the next generation of biomedical researchers. Read more
*Offer only available for the duration of your active subscription, and subject to change. You MUST claim your prize within 72 hours, if not we will redraw.
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