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Structural Biology PhD Projects, Programmes & Scholarships in the UK

We have 97 Structural Biology PhD Projects, Programmes & Scholarships in the UK

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Biological Sciences

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We have 97 Structural Biology PhD Projects, Programmes & Scholarships in the UK

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Role of APC/C subunit post-translational modifications on the function of the APC/C in mitosis

The APC/C is a large macromolecular E3 ubiquitin ligase, that, through targeting protein substrates for polyubiquitylation and 26S proteasome-mediated degradation coordinates the progression of cells through mitosis (1, 2). Read more

In situ HDX-MS of membrane protein-ligand interactions

The project aims to develop an HDX-MS workflow to profile ligand-membrane protein interactions. The identification of hits with high selectivity constitutes an important landmark for the design and development of novel therapeutics. Read more

Structure and function of Batten disease proteins

The neuronal ceroid lipofucscinoses are a group of inherited neurodegenerative disorders with primarily childhood onset. The most common form, also known as Batten disease or CLN3 disease, is caused by recessively inherited mutation in the CLN3 gene. Read more

BeAST: Bio-electrochemical Applications for Sustainable Technologies

Use of fossil fuels by humans has littered the planet and increased greenhouse gas emissions in the air leading to a Climate Emergency. Read more

In silico glycosylation of AlphaFold protein structural models.

Background. The recent release of the AlphaFold Protein Structure Database by DeepMind and EMBL-EBI has made available to the scientific community highly accurate structural predictions for 20,000 human proteins and those from 20 other biologically relevant organisms. Read more

Engineering Enzymes for Organic Synthesis

Engineering Enzymes for Organic Synthesis. Professor Gideon Grogan, Department of Chemistry, University of York. Background. Our research group is interested in the identification and characterisation of enzymes and their application to organic synthesis. Read more

Protein degradation-based gene therapies for neurodegenerative disease

Proteins fold like origami into complex three-dimensional shapes. This process can malfunction and result in misfolded proteins that stick together to form large aggregates. Read more

Structural and biological characterisation of virulence factor in Gram-negative pathogens affecting aquaculture

Gram-negative pathogens are responsible for major disease problems in humans and animals, and a better understanding of the mechanisms for how these bacteria cause infections is key to identifying more effective ways to prevent and treat outbreaks. Read more
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Ultrastructural insights into avian herpesvirus-host cell interactions

Marek’s disease virus (MDV) is a major avian alphaherpesvirus associated with Marek’s disease (MD) in poultry characterised by rapid-onset T-cell lymphomas, immunosuppression and paralysis causing annual economic losses of around $2 billion worldwide. Read more

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