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We have 109 Structural Biology PhD Projects, Programmes & Scholarships in the UK
Structural Biology PhD Projects, Programmes & Scholarships in the UK
We have 109 Structural Biology PhD Projects, Programmes & Scholarships in the UK
Beyond Lysine: Exploring the Functional Consequences of Non-Canonical Ubiquitination in Health and Disease
Ubiquitination is a fundamental post-translational modification (PTM) crucial for a wide range of cellular processes, including protein degradation, localization, quality control, DNA repair, cell signalling, and immune responses. Read more
Decoding the mechanism and function of UFMylation in ER Quality Control
Approximately one third of the human proteome depends on the endoplasmic reticulum (ER) for its biosynthesis. Read more
Translating Deep Learning protein bioinformatics methods to accelerate structural determination by X-ray crystallography
Even after the AlphaFold 2 (AF2) revolution, experimental structural biology contributes enormously to advances across all areas of biology. Read more
Investigating the interaction of La related proteins with colliding ribosomes
The accurate translation of mRNA into the right proteins at the right time and place is a critical cellular biological process for all life. Read more
Emerging Continuous Light-based Volumetric 3D Printing Methods
At the Programmable Biomaterials Lab (PBL), our goal is to solve some of the major challenges facing large-scale and high-throughput bioproduction via innovative 3D light-assisted programming of matter. Read more
The biology of plasmids in human adapted pathogens
Plasmids are extrachromosomal elements in bacteria that confer virulence and resistance against antimicrobials. In the host adapted pathogens, Shigella and Neisseria gonorrhoeae, plasmids have established long evolutionary links with the bacterial species. Read more
Selection and evaluation of new universal influenza vaccine candidates using monoclonal antibodies and digitally designed HA and NA libraries & pseudotype virus screens
Universal influenza vaccines are a major global R&D vaccine priority. The Temperton (ORCID. Read more
Selection and evaluation of new universal influenza vaccine candidates using monoclonal antibodies and digitally designed HA and NA libraries & pseudotype virus screens
Universal influenza vaccines are a major global R&D vaccine priority. The Temperton (ORCID. Read more
Molecular mechanisms and physiological consequences of bacterial virulence proteins
Many intracellular bacterial pathogens deliver virulence (effector) proteins through dedicated secretion systems into mammalian host cells. Read more
Cryo-EM and tomography studies of dynein-2 motor action and regulation
Dyneins are motor proteins in eukaryotic cells. Axonemal isoforms power flagellar beating, cytoplasmic dynein-1 transports cargoes in the cell interior, and dynein-2 – the focus of this project – is essential for the assembly and signalling functions of cilia and flagella. Read more
Rhomboid-like proteins: from mechanisms to human disease
We study membrane proteins and how they control signalling and cellular responses to stress. Read more
Chaperone mediated assembly of ciliary dynein motors
All cellular proteins are made as long strings of amino acids called polypeptide chains. How these chains get folded into their unique 3‐dimensional shapes so they can perform their unique cellular functions remains an outstanding question in biology. Read more
How membrane proteins are trafficked into cilia for sensory functions
Cilia are organelles on the surface of eukaryotic cells that are packed with membrane proteins. In humans, ciliary membrane proteins are responsible for detecting light, smell, morphogens, and ligands involved in complex processes such as appetite control. Read more
Regulation of genome stability and human disease
Poly(ADP-ribose) polymerases (PARPs) are the major family of enzymes that synthesize an abundant posttranslational protein modification called ADP-ribosylation. Read more
Molecular mechanisms of genome stability and cancer
The maintenance of complete and undamaged genome is critical for survival. However, DNA is a fragile structure susceptible to DNA damage. Read more