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We have 109 Structural Biology PhD Projects, Programmes & Scholarships in the UK
Structural Biology PhD Projects, Programmes & Scholarships in the UK
We have 109 Structural Biology PhD Projects, Programmes & Scholarships in the UK
Understanding KANK1 contribution to neuronal health and disease.
Motor Neurone Disease (MND) is a catastrophic disease with a 100% fatality rate but is mechanistically poorly understood. Recently, αβ-integrin heterodimers have been implicated in neurodegeneration. Read more
Mechanisms of protein quality control in health and disease
Accumulation of misfolded proteins and aberrant protein aggregates are hallmarks of a wide range of pathologies such as neurodegenerative diseases and cancer. Read more
Understanding the Principles of Organelle Biogenesis
Eukaryotic cells are packed with organelles, the number and size of which appear to be tightly regulated. Read more
Protein self assembly induced by multivalent biological metabolites
In addition to being an energy source in biological reactions, recent discoveries suggest adenosine triphosphate (ATP) also plays a critical role in maintaining cell stability and preventing deleterious cellular processes through modulating biomacromolecular self assembly. Read more
Developing novel light-induced in-situ Electron Paramagnetic Resonance (EPR) methods
Light-induced in-situ Electron Paramagnetic Resonance (EPR) studies are a growing field in both continuous wave and pulsed EPR. It can be used to monitor photoactivated chemical and biochemical reactions involving radical reagents, projects or intermediates. Read more
Redefining DNA-double strand break repair in humans
Numerous DNA damaging agents constantly cause damage to cellular DNA. Read more
The role of inflammatory cytokines on macrophage cytoskeletal structure and function in diabetes and cardiovasular disease
The Maelor Academic Unit of Medical & Surgical Sciences (MAUMSS) is a novel initiative by the Betsi Cadwaladr University Health Board (BCUHB), and is designed to encourage and support research within the Health Board and to promote academic activity, basic science and clinical research across North Wales (UK) and beyond. Read more
Structural biology tools to investigate and target ubiquitin system proteases in cancer
Ubiquitination targets proteins for degradation and regulates virtually all cellular signalling pathways in eukaryotes. The human genome encodes over 50 ubiquitin specific proteases (USPs) that cleave ubiquitin from modified proteins to salvage them from proteasomal degradation. Read more
Advancing Liquid Atmospheric Pressure (LAP) MALDI Mass Spectrometry
MALDI. mass spectrometry has been a cornerstone of modern biological mass. spectrometry, enabling the soft ionization, analysis and characterisation of. Read more
Alpha-synuclein amyloid in Parkinson's disease: using Nanoinjection as a tool to study alpha-synuclein amyloid toxicity inside neurons
Intraneuronal inclusions known as Lewy bodies are a hallmark of Parkinson’s disease. Amyloid fibrils formed by the misfolding of alpha-synuclein are the principal component of Lewy Bodies. Read more
Control and inhibition of virus replication
The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specifically Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets. Read more
Delivery and misdelivery of outer membrane proteins to the BAM complex using cryoEM
The BAM complex folds membrane proteins into the outer membrane of Gram-negative bacteria, proteins whose functions are essential for bacterial viability, pathogenicity and virulence. Read more
Design and Folding of beta barrel membrane proteins
The cell walls of Gram negative bacteria are packed with b-barrel outer membrane proteins (OMPs) whose function are essential for bacterial growth and virulence. Read more
Elucidating the molecular mechanisms of intrinsic antibiotic resistance in bacterial pathogens
Antibiotics make possible the treatment and cure of life-threatening bacterial infections and have added over a decade to the average human lifespan. Read more
Self-funded PhD- Understanding Cell Biology through Imaging
We study the trafficking and interaction of molecules and structures inside cells. Extracellular signals need to be processed in a correct manner for a cell to function properly. Read more