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We have 118 Structural Biology PhD Projects, Programmes & Scholarships in the UK
Structural Biology PhD Projects, Programmes & Scholarships in the UK
We have 118 Structural Biology PhD Projects, Programmes & Scholarships in the UK
The role of inflammatory cytokines on macrophage cytoskeletal structure and function in diabetes and cardiovasular disease
The Maelor Academic Unit of Medical & Surgical Sciences (MAUMSS) is a novel initiative by the Betsi Cadwaladr University Health Board (BCUHB), and is designed to encourage and support research within the Health Board and to promote academic activity, basic science and clinical research across North Wales (UK) and beyond. Read more
Structural biology tools to investigate and target ubiquitin system proteases in cancer
Ubiquitination targets proteins for degradation and regulates virtually all cellular signalling pathways in eukaryotes. The human genome encodes over 50 ubiquitin specific proteases (USPs) that cleave ubiquitin from modified proteins to salvage them from proteasomal degradation. Read more
Advancing Liquid Atmospheric Pressure (LAP) MALDI Mass Spectrometry
MALDI. mass spectrometry has been a cornerstone of modern biological mass. spectrometry, enabling the soft ionization, analysis and characterisation of. Read more
Alpha-synuclein amyloid in Parkinson's disease: using Nanoinjection as a tool to study alpha-synuclein amyloid toxicity inside neurons
Intraneuronal inclusions known as Lewy bodies are a hallmark of Parkinson’s disease. Amyloid fibrils formed by the misfolding of alpha-synuclein are the principal component of Lewy Bodies. Read more
Control and inhibition of virus replication
The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specifically Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets. Read more
Delivery and misdelivery of outer membrane proteins to the BAM complex using cryoEM
The BAM complex folds membrane proteins into the outer membrane of Gram-negative bacteria, proteins whose functions are essential for bacterial viability, pathogenicity and virulence. Read more
Design and Folding of beta barrel membrane proteins
The cell walls of Gram negative bacteria are packed with b-barrel outer membrane proteins (OMPs) whose function are essential for bacterial growth and virulence. Read more
Elucidating the molecular mechanisms of intrinsic antibiotic resistance in bacterial pathogens
Antibiotics make possible the treatment and cure of life-threatening bacterial infections and have added over a decade to the average human lifespan. Read more
Self-funded PhD- Understanding Cell Biology through Imaging
We study the trafficking and interaction of molecules and structures inside cells. Extracellular signals need to be processed in a correct manner for a cell to function properly. Read more
Self-funded MSc R: Understanding Cell Biology Through Imaging
We study the trafficking and interaction of molecules and structures inside cells. Extracellular signals need to be processed in a correct manner for a cell to function properly. Read more
Probing Death Decisions from Morphogen Gradient Fields
Morphogen gradient scaling is one of the hottest fields in developmental biology at the moment. Scaling is fundamental, explaining how the machinery that controls pattern formation in development (the morphogens) can adapt, so that organs of different sizes show morphological structures which are proportioned. Read more
Targeting the mechanism of small GTPase splice variant RAC1B using ligand design
RAC1 is a small GTPase protein that functions as a key signalling node downstream of various microenvironmental signalling pathways. Read more
Advanced Electron Paramagnetic Resonance (EPR) spectroscopy – method development and applications
Electron Paramagnetic Resonance (EPR) spectroscopy is a magnetic resonance technique that is exclusively and exquisitely sensitive to unpaired electrons that are found in radicals and paramagnetic metal complexes. Read more
Alterations in reparative dentinogenesis with ageing, gender and genetic predisposition
Dental pulp exposure caused by tooth decay or injury can lead to life-threatening infections. Following injury, reparative dentinogenesis serves a vital purpose through the accelerated generation of tertiary dentine, comprising mineral and type I collagen. Read more
Exploiting Deep Learning-based protein structure prediction for function annotation and structural biology
Applications will be reviewed until a suitable candidate is appointed. Protein structural information is crucial for an understanding of protein function and evolution. Read more