The major innate immune response against viruses, the type I interferon response, is inactive during the very early days of embryonic development. Read more
Influenza A virus circulates globally in migratory wild aquatic birds, frequently but unpredictably spilling over into domestic poultry, causing huge economic burden. Read more
Second Supervisor. Prof. Ian Sayers, Centre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham. Read more
We invite applicants for a 4-year iCASE studentship to work in collaboration with our industrial partner Carus Animal Health. Second Supervisor. Read more
Nucleosides are essential components of DNA, RNA, and other molecules that are vital for cell function. Therefore, nucleoside analogues have long been employed as drugs to combat cancer, viral infections, and microbial diseases. Read more
Are you fascinated by the interplay between viruses and their hosts? Join our cutting-edge research team to uncover the molecular secrets behind RNA virus persistence. Read more
Crustacean diseases cause economic damage to industry and the environment. Billions are lost on a yearly basis due to disease in crustacean aquaculture and, in wild systems, crustaceans commonly introduce disease-causing microbes as biological invaders. Read more
Vector-borne diseases afflict humans, livestock and plants – according to WHO, vector-borne diseases comprise ~17% of all infectious disease of humans – and also threaten biodiversity by their impact on endangered species. Read more
Ageing is one of the biggest mortality risk factors to a range of zoonotic RNA viruses including influenza and SARS-COV-2. Infected cells activate RNA sensing pathways to promote inflammation and leukocyte mediated recruitment. Read more
Gene therapies are novel therapeutic approaches for rare genetic diseases. One key technology for gene therapies are engineered viral vectors, especially recombinant Adeno-associated Viruses (rAAVs). Read more
Campylobacter jejuni is a major foodborne pathogen responsible for thousands of cases gastroenteritis every year. The major source of infections by this bacterial pathogen is contaminated poultry products. Read more
Insects vector globally important diseases in agriculture, posing significant economic burdens and threatening food security. Virus transmission by sap-sucking insects account for nearly half of all plant pathogens, leading to >£24 billion in global annual costs. Read more
Project description. Even several years after its emergence, SARS-CoV-2 is still a global disease impacting millions of lives where new variants appear to influence the efficacy of vaccines dramatically. Read more
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