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University of Dundee PhD Projects, Programmes & Scholarships
We have 149 University of Dundee PhD Projects, Programmes & Scholarships
We have 149 University of Dundee PhD Projects, Programmes & Scholarships
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How cells regulate chromosome segregation in mitosis and how this goes wrong in cancer
Human cells store their genetic information in 46 chromosomes. To maintain this vital genetic information, a complete set of chromosomes must be inherited precisely by each daughter cell after cell division. Read more
Epigenetic signalling in cancer
The advent of population scale tumour genomics has revealed that the genes encoding proteins that normally act to regulate chromatin structure are amongst the most frequently mutated genes in a range of cancers. Read more
How does Dysregulated Signal Transduction cause Intellectual Disability?
The goal of our lab is to understand how signal transduction is disrupted to cause intellectual disability, which is a major healthcare challenge world-wide. Read more
Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signalling
Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more
Structural and Mechanistic Chemical Biology of Degraders Mode of Actions
Pioneering discoveries from the Ciulli Laboratory have contributed to the establishment of a new modality of chemical intervention into biological systems. Read more
Activation Mechanisms of Ubiquitin E3 ligases
E3 ligases are a startling class of enzyme that attach the small protein ubiquitin to substrates and regulate virtually all aspects of the cell. Read more
How does the TRAIP ubiquitin ligase guard the mammalian genome from damage?
The TRAIP ubiquitin ligase is a key regulator of genome integrity in mammalian cells. The importance of TRAIP is highlighted by the fact that mutation… Read more
Location, location, location: DNA damage sensors which launch protective responses to DNA damage
DNA damage happens at very high frequency in the cells in our bodies – meaning that the blueprint for the proper functioning of cells could be altered unless the mistakes are spotted and corrected. Read more
Rewiring cell signalling by targeted protein degradation and dephosphorylation
Post-translational modifications on proteins, such as reversible ubiquitylation and phosphorylation, are fundamental to controlling cellular signalling through regulation of protein stability and function. Read more
Finding the eat-me signals
The Ganley lab is interested in unravelling the molecular mechanism of autophagy (which literally translates from the Greek meaning to eat oneself). Read more
Protein Quality Control pathways at the endoplasmic reticulum
Around 30% of the proteome, including secretory proteins, plasma membrane proteins, and proteins targeted to organelles require the endoplasmic reticulum (ER) for their biosynthesis. Read more
Genome-wide screening approach to uncover novel regulators of organelle-selective autophagy
Autophagy was once thought to be a bulk, non-selective degradative pathway that cells employ during nutrient deprivation to rapidly break down cellular content for energy generation. Read more
Degrade or die
The Rousseau lab is interested in decoding how protein degradation by the proteasome is regulated in cells so that accumulation of unfolded, misfolded, or damaged proteins can be cleared before they become deleterious. Read more
The antiviral roles of ISG15 modifications
One of the most important challenges facing biomedical research is to understand the molecular details of how our immune system defends against pathogens. Read more
Heat shapes plant growth - unravelling crosstalk between temperature and hormone signalling pathways in the control of leaf development
Ambient temperature has profound effects on almost all aspects of plant development, from the onset of seed germination and seedling establishment to flower and fruit production, and thereby also impacts crop quality and yield. Read more