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University of Dundee PhD Projects, Programmes & Scholarships

We have 149 University of Dundee PhD Projects, Programmes & Scholarships

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We have 149 University of Dundee PhD Projects, Programmes & Scholarships

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How cells regulate chromosome segregation in mitosis and how this goes wrong in cancer

Human cells store their genetic information in 46 chromosomes. To maintain this vital genetic information, a complete set of chromosomes must be inherited precisely by each daughter cell after cell division. Read more

Epigenetic signalling in cancer

The advent of population scale tumour genomics has revealed that the genes encoding proteins that normally act to regulate chromatin structure are amongst the most frequently mutated genes in a range of cancers. Read more

Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signalling

Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more

Structural and Mechanistic Chemical Biology of Degraders Mode of Actions

Pioneering discoveries from the Ciulli Laboratory have contributed to the establishment of a new modality of chemical intervention into biological systems. Read more

Location, location, location: DNA damage sensors which launch protective responses to DNA damage

DNA damage happens at very high frequency in the cells in our bodies – meaning that the blueprint for the proper functioning of cells could be altered unless the mistakes are spotted and corrected. Read more

Rewiring cell signalling by targeted protein degradation and dephosphorylation

Post-translational modifications on proteins, such as reversible ubiquitylation and phosphorylation, are fundamental to controlling cellular signalling through regulation of protein stability and function. Read more

Protein Quality Control pathways at the endoplasmic reticulum

Around 30% of the proteome, including secretory proteins, plasma membrane proteins, and proteins targeted to organelles require the endoplasmic reticulum (ER) for their biosynthesis. Read more

Degrade or die

The Rousseau lab is interested in decoding how protein degradation by the proteasome is regulated in cells so that accumulation of unfolded, misfolded, or damaged proteins can be cleared before they become deleterious. Read more

Heat shapes plant growth - unravelling crosstalk between temperature and hormone signalling pathways in the control of leaf development

Ambient temperature has profound effects on almost all aspects of plant development, from the onset of seed germination and seedling establishment to flower and fruit production, and thereby also impacts crop quality and yield. Read more

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