Supervisors. Tom Thomson (NEST) in collaboration with Neil Telling (Keele). Advances in conventional cancer treatments such as chemotherapy and radiotherapy have provided vast improvements in cancer survival rates over recent years.
Background and goals. Cells respond appropriately to their surroundings by activating plasma membrane spanning receptors like Receptor Tyrosine Kinases (RTKs) and thereby adapting long-term outputs (e.g.
Hydrogels are biomaterials used to prepare in vitro models used to study many biological processes. These materials can be selectively modified to present different physical, chemical and mechanical properties to mimic the ones of the extracellular matrix present in different tissues.
Background. Endometrial cancer and endometriosis are common gynaecological disorders, which arise from the uterine lining. Cancer develops by glandular cell differentiation, whilst implantation and growth of endometrial-like tissue in endometriosis induces a chronic inflammatory reaction causing pain and infertility.
Defects in the cell cycle are the underlying basis to cancer. Work in my lab is aimed at understanding the molecular basis to tumourigenesis through studying pathways which impact on the cell cycle and are deregulated in cancer.