IAPETUS is the North East of England's and Scotland's multidisciplinary Doctoral Training Partnership (DTP) for the environmental sciences, which is funded and accredited by NERC.
Research Group:
Biomedical Sciences Research Centre
Dr CM Czekster, Prof D Harrison
Application Deadline:
15 February 2019
Background and project details. Lung cancer is the most common cause of cancer deaths in both males and females. In the UK, of the total deaths caused by cancer 21% are caused by lung cancer alone.
Free radical-mediated C–C bond forming reactions are powerful and versatile tools in organic synthesis due to their mild reaction conditions and high functional group tolerance.
Research in the O’Hagan Group has had a major focus on the synthesis of novel organofluorine motifs, and in particular placing fluorines stereoselectively around aliphatic ring systems.
Research in the O’Hagan group has had a focus on the biosynthesis of fluorine containing natural products and the identification of a fluorination enzyme, ‘the fluorinase’, from Streptomyces cattleya.[1] Fluorine is very rare in nature, and in those rare cases where an organism can form a C-F bond from fluoride ion, then the enzymology is unique and interesting.
Log-linear modelling is the standard approach for investigating the full joint dependence structure between categorical variables such as phenotypes and SNPs.
An experiment to profile e.g. proteins or messenger RNAs will capture a sample of those molecules. There will be a random element to the sample but, depending on the technology used, there will be characteristics that influence the chances of seeing a particular molecule.
Research Group:
Centre for Research into Ecological and Environmental Modelling
Prof L Thomas, Dr R Glennie
Applications accepted all year round
Ecologists collect data on wild animal populations by a variety of survey methods and infer from these how the population changes over time through recruitment, survival, and movement processes.
