Research into fundamental mechanisms in Infection and Immunity has led to important advances in our understanding of the molecular and cellular pathogenesis of disease and the control of the immune system.
The thymus is the primary lymphoid organ for the generation of naïve T cells. The laboratory’s scientific focus is to define the genetic control of thymus development and function in health and disease.
Macrophages are cells of the innate immune system that have the essential functions of eliminating infectious agents, removing infected, dying and dead cells, and inducing, regulating and resolving inflammation.
The macrophage is an evolutionarily ancient sentinel of the health of all of the body’s tissues. clearing away dead cells and debris; as brain-resident microglia, remodelling defunct neuronal connections; nurturing tissue stem cells; detecting and responding to pathogens.