University of York, York Biomedical Research Institute PhD Projects, Programs & Scholarships
We have 9 University of York, York Biomedical Research Institute PhD Projects, Programs & Scholarships
We have 9 University of York, York Biomedical Research Institute PhD Projects, Programs & Scholarships
Metal-mediated chemical protein modification
Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more
Self-funded BMS project: Nutrient-Mediated Bacterial Delivery of ‘Dual Warhead’ Antimicrobials
Microbial resistance to antibiotics has been a growing problem. Until recently, antibiotics of the fluoroquinolone-type provided some of the most active broad-spectrum antibacterial agents on the market. Read more
Self-funded BMS project: Resurrecting ancestral human sugars: a novel approach to cancer immunotherapy
Human cell surfaces are coated in a thick layer of sticky sugars [Glycocalyx]. Uniquely, cancer cells are covered with an excess of a sialic acid sugar (Neu5Ac), acting as ‘camouflage’ to avoid the immune system. Read more
Self-funded BMS project: Cytokine-dependent immune cell modulation through trained immunity
Your innate immune system is the first line of defence against infections, cancer and various physiological danger signals. Innate immune dysregulation is a central driver of various pathologies ranging from neurological diseases to immunological and metabolic disorders and cancers. Read more
Self-funded BMS project: Structural architecture of vaccine targets for the parasitic livestock disease animal African trypanosomiasis.
The livelihoods of millions of people living in Africa are at risk due to infectious diseases that affect the health of livestock animals that they depend on for essential food, milk, clothing and draught power. Read more
Self-funded BMS project: Regulation of Leishmania cellular remodelling during life cycle transition
This project aims to investigate the signalling pathways that regulate key events in the life cycle of Leishmania and which protein kinases are essential and therefore potentially responsive to chemotherapeutic modulation. Read more
Self-funded BMS project: The ecology, evolution and treatment of polymicrobial cystic fibrosis lung infections
The global use and misuse of antibiotics has led to the evolution and spread of bacterial resistance to all routinely used antibiotics. Read more
Self-funded BMS project: Understanding and targeting the hypoxic response in acute myeloid leukaemia (AML)
Hypoxia-inducible factor (HIF) is a master regulator of transcription, and its function is centrally involved in both normal haematopoiesis and in malignant transformation of blood cells causing acute myeloid leukaemia (AML). Read more
Self-funded BMS project: Elucidating Novel Targets for the Treatmeant of Estrogen Receptor Positive (ER+) Breast Cancer
The estrogen receptor is one of several nuclear receptors that play a key role in the progression and treatment of several forms of cancer, including leukemia, breast and prostate cancer. Read more
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