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University of York, York Biomedical Research Institute PhD Projects, Programs & Scholarships

We have 9 University of York, York Biomedical Research Institute PhD Projects, Programs & Scholarships

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York Biomedical Research Institute  University of York

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We have 9 University of York, York Biomedical Research Institute PhD Projects, Programs & Scholarships

Metal-mediated chemical protein modification

Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more

Self-funded BMS project: Nutrient-Mediated Bacterial Delivery of ‘Dual Warhead’ Antimicrobials

Microbial resistance to antibiotics has been a growing problem. Until recently, antibiotics of the fluoroquinolone-type provided some of the most active broad-spectrum antibacterial agents on the market. Read more

Self-funded BMS project: Resurrecting ancestral human sugars: a novel approach to cancer immunotherapy

Human cell surfaces are coated in a thick layer of sticky sugars [Glycocalyx]. Uniquely, cancer cells are covered with an excess of a sialic acid sugar (Neu5Ac), acting as ‘camouflage’ to avoid the immune system. Read more

Self-funded BMS project: Cytokine-dependent immune cell modulation through trained immunity

Your innate immune system is the first line of defence against infections, cancer and various physiological danger signals. Innate immune dysregulation is a central driver of various pathologies ranging from neurological diseases to immunological and metabolic disorders and cancers. Read more

Self-funded BMS project: Regulation of Leishmania cellular remodelling during life cycle transition

This project aims to investigate the signalling pathways that regulate key events in the life cycle of Leishmania and which protein kinases are essential and therefore potentially responsive to chemotherapeutic modulation. Read more

Self-funded BMS project: Understanding and targeting the hypoxic response in acute myeloid leukaemia (AML)

Hypoxia-inducible factor (HIF) is a master regulator of transcription, and its function is centrally involved in both normal haematopoiesis and in malignant transformation of blood cells causing acute myeloid leukaemia (AML). Read more
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