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We have 21 University of York, York Biomedical Research Institute PhD Projects, Programmes & Scholarships

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York Biomedical Research Institute  University of York

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University of York, York Biomedical Research Institute PhD Projects, Programmes & Scholarships

We have 21 University of York, York Biomedical Research Institute PhD Projects, Programmes & Scholarships

Exploring Viral Nucleic Acid Machinery via Cryo Electron Microscopy to Advance Biomedicine

Viruses, these tiny but potent life forms, are all around us, infecting various organisms and directly affecting human health. Although in most cases, viral infection is not life threatening, in the minority of cases it leads to long-term disorders including cancer. Read more

Understanding how mutations in the kinase TLK2 cause a neurodevelopmental disorder

Tousled-like kinase 2 (TLK2) was recently identified as a novel genetic locus for a neurodevelopmental disorder. Patients predominantly possess de novo mutations in TLK2, leading to a reduction in its expression or kinase activity. Read more

Understanding Hormone Regulation in Skin Cancer Development and Progression

Skin cancers, including melanoma and non-melanoma skin cancers, pose a significant global health burden. While the role of hormones in skin cancer development and progression remains an underexplored area, recent research has suggested potential links between hormonal regulation and skin cancer outcomes. Read more

Role of the endosomal pathway in regulating sleep and circadian rhythms

Ageing and many neurodegenerative disorders are characterised by a progressive loss of neurons in particular brain regions leading to behavioural changes including cognitive decline, sleep disruption and circadian dysregulation. Read more

Discovery and functional investigation of the shared molecular mechanisms of host immunoregulation by the pathogens that cause malaria and sepsis.

Infectious diseases cause enormous humanitarian and economic burdens worldwide. Designing interventions that prevent, cure, or control many infections is difficult because pathogens have evolved sophisticated ways of subverting host immunity. Read more

Modulation of host immune response by secreted proteins from parasitic worms

Background. To establish chronic infection, parasitic worms manipulate their mammalian hosts’ immune system. This immune modulation is often mediated by excreted or secreted parasite glycoproteins (ES proteins). Read more

Chemical modification of proteins via metal-mediated processes

Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more

Understanding interactions of proteins with polymer-coated nanoparticles

Introduction. Polymer-coated nanoparticles are promising drug delivery vehicles. Multiple functionalities can be embedded into the nanoparticle structure to enable uptake of the drug-like molecules, their targeted delivery and controlled release. Read more

Ion channel signalling in cancer cells

Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more

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