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We have 19 University of York, York Biomedical Research Institute PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
University of York, York Biomedical Research Institute PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 19 University of York, York Biomedical Research Institute PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Understanding the role of inflammation and immune selection in the context of clonal haematopoiesis and blood cancer
This PhD studentship is funded via an NIHR grant supporting collaboration between clinicians and scientists at St. James's hospital, Leeds, the Centre for Blood Research, Biology Department, York, and the Epidemiology and Cancer Statistics Group, York. Read more
Bio-photonic and molecular characterization of gastric cancer tissue to improve early diagnosis
Gastric Cancer is the fifth most common malignancy in the world and third leading cause of death. 865,000 worldwide in 2017; 12 lives/day in the UK (2016-2018). Read more
Studying protein homeostasis in healthy and malignant stem cell development
The Grey lab studies the role of protein homeostasis in healthy and malignant haematopoietic (blood) stem cell development. We focus on the proteome of healthy stem cells as they mature in vivo, expand in vitro and their therapeutic use for bone marrow transplantation. Read more
Delineating the functional organisation of medial prefrontal cortex
The medial prefrontal cortex (mPFC) is implicated in a diverse set of cognitive domains, including executive control, speech and language, memory and social cognition. Read more
Studying the nitrogen cycle by advanced NMR methods
Nitrogen is present in our environment in a wide variety of forms that include organic nitrogen, ammonium, nitrite, nitrate, nitrous oxide, nitric oxide and nitrogen gas. Read more
Unravelling mechanisms of cytoskeletal regulation that control neuronal health and disease
Axons are the slender, often meter-long processes of neurons which electrically wire the brain. These delicate structures are up to a meter long and need to be maintained for decades. Read more
Unlocking the non-coding secrets of the human immune system
Thousands of long non-coding RNAs (lncRNAs) have been discovered in mammalian transcriptomes. LncRNAs act through a multitude of mechanisms affecting transcription and co- and post-transcriptional mRNA processing in a cell. Read more
Towards New Antivirals for the Treatment of COVID-19: Fragment-Based Lead Generation of Small Molecule Inhibitors of the Nsp3 Macrodomain in SARS-CoV-2
Background. Coronaviruses (CoVs) are important human pathogens and SARS-CoV-2 is responsible for the COVID-19 pandemic. Notwithstanding progress in available vaccines for COVID-19, there remains a need to develop small molecule drug candidates for treating COVID-19. Read more
Tissue-specific roles of human endogenous retroviruses in urothelial carcinoma
Human endogenous retroviruses (HERVs) are the remnants of retroviral infections in our evolutionary past that contribute 8% of our genome. Read more
Therapeutic potential of extracellular vesicles from different mesenchymal stem cell subtypes
Human mesenchymal stem/stromal cells (MSCs) are found in adult tissues such as bone marrow and are able to differentiate into bone, cartilage and fat tissues. Read more
The development of metal-based antibiotics
Background. Due to the widespread rise in microbial resistance, new classes of antimicrobial agents are urgently needed. However, only very few of the compounds in clinical development represent new structural classes. Read more
Role of the endosomal pathway in regulating sleep and circadian rhythms
Ageing and many neurodegenerative disorders are characterized by a progressive loss of neurons in particular brain regions leading to behavioural changes including cognitive decline, sleep disruption and circadian dysregulation. Read more
New protein modification chemistries for studying protein structure and function
Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more
Ion channel signalling in cancer cells
Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more
Indentifying the regulators of the Estrogen Receptor in Breast Cancer
Approximately 70% of breast cancer cases are Oestrogen Receptor positive (ER+). In these patients, the ER drives the growth and proliferation of the tumour. Read more
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