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Organic Chemistry PhD Projects, Programs & Scholarships in York

We have 10 Organic Chemistry PhD Projects, Programs & Scholarships in York

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  Synthesis of medicinally important macrocycles via Successive ring expansion
  Dr W Unsworth
Applications accepted all year round

Funding Type

PhD Type

Traditionally, medium sized rings and macrocycles are made by forming a chemical bond between the two ‘ends’ of a long linear molecule (A), but competing side reactions and/or dimerisation reactions usually dominate in such processes, leading to inefficient reaction processes.
  A dynamic biomaterial-ligand tethering strategy for tissue engineering
  Dr C Spicer, Prof D K Smith
Applications accepted all year round

Funding Type

PhD Type

Biomaterials that can trigger the repair of damaged tissues have the potential to revolutionise the way we treat disease. Materials that can present cells and tissues with powerful biochemical signals, through attached peptides, proteins, and carbohydrates, are particularly effective at controlling regeneration.
  Dual-Action Anti-Cancer Drug Delivery Vehicles
  Prof D K Smith
Applications accepted all year round

Funding Type

PhD Type

Cancer is a challenging disease target, and requires wide-ranging strategies for intervention. Given the difficulties in treating recalcitrant tumours, multi-mode therapies are of significant potential value.
  Decision making through artificial chemical intelligence
  Dr J Slattery, Prof I J S Fairlamb
Applications accepted all year round

Funding Type

PhD Type

Automation will transform the chemical landscape. Powerful robotic platforms can perform reactions or analyses much more rapidly than traditional approaches.1 Ever faster computers allow huge numbers of molecules to be studied in an automated way using computational chemistry.
  Turning organocatalysts green
  Dr A Routledge, Prof M North
Applications accepted all year round

Funding Type

PhD Type

Organocatalysis (catalysis using organic molecules) fulfils two green chemistry guidelines1 by avoiding the use of rare metals, and by being catalytic.
  The greening of peptide synthesis
  Prof M North
Applications accepted all year round

Funding Type

PhD Type

Peptide synthesis (both solution and solid state) is of fundamental importance to the pharmaceuticals sector. They are therefore expected to play a major role in the future of drug discovery.
  Biomass derived synthetic polymers
  Prof M North
Applications accepted all year round

Funding Type

PhD Type

Polymers are produced on a multi-million tonne scale per annum and are a high priority to move from non-sustainable petroleum based to sustainably based starting materials.
  Brønsted Acid Catalysed Asymmetric Synthesis of Cyclic Ethers
  Dr P Clarke
Applications accepted all year round

Funding Type

PhD Type

Over recent years there has been a drive by medicinal chemists to explore more 3-dimensional areas of chemical space. Cyclic ethers, such as the tetrahydropyran (THP) and the tetrahydrofuran (THF) rings, are the most common and 6th most common saturated heterocyclic function present in marketed pharmaceuticals.
  Studies on the Total Synthesis of Anthracimycin and Related Natural Products
  Dr P Clarke
Applications accepted all year round

Funding Type

PhD Type

Anthracimycin 1 and chlorotonil A 2 exhibit extremely potent activity as antibiotic agents, while streptosetin A 3 has anti-tumour activity.
  A new route to functionalised, stable Blatter-type free radicals
  Dr V Chechik
Applications accepted all year round

Funding Type

PhD Type

Although most free radical are highly reactive and have very limited lifetime, some possess excellent stability. The magnetic properties of unpaired electron make such radicals promising building blocks for magnetic materials.
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