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PhD Studentships in Chemistry, Biology, Pharmacy

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PhD Studentships in Pharmacy


Design and characterisation of novel mucoadhesive drug delivery systems and in vitro mucus models

Targeting using mucoadhesive devices enhances the therapeutic efficacy of drugs for treatment of disorders of the eyes, mouth, gastrointestinal and reproductive tracts, e.g. oropharyngeal candidiasis and Helicobacter-pylori infection. Advantages include targeting local infections, enhancing systemic bioavailability and minimising side-effects. This project involves development of novel mucoadhesive polymers, targeted to mucosal sites and design of models to simulate diffusion/permeation across musosae, limiting requirements for animals and problems with degradation of native mucus. This project should attract those wanting a career in pharmaceutical development and training will be given in several techniques including HPLC, MS, NMR, XRD, FT-IR, DSC, NTA, SEM, tensiometry, rheology, tissue/cell culture, histology and dissolution testing.

Contact Dr Adeola Adebisi [email protected] 01484 473856

Antidiabetics in United Kingdom: Evaluating prescription patterns, drug utilisation and health outcomes

The number of patients with diabetes continues to rise in recent years, however, it is not clear how physicians in the UK are making choices to treat diabetes, and how compliant patients are in taking antidiabetics. Understanding drug utilization trends, prescribing patterns, and economic burden of medicines will help optimize drug therapy. The aims of this research are to measure medicines utilization, prescription trends and to determine the overall costs impact of antidiabetics. The other objectives are to explore GPs and pharmacists opinion towards rational pharmacotherapy. Treatment satisfaction and quality of life of patients would also be assessed in this research.

Contact Professor Zaheer Babar [email protected] 01484 471471

Availability, affordability and pricing of high cost medicines in United Kingdom

In the UK a large majority of drugs are funded, however, there are reports that certain high-cost medicines (HCMs) including newer cancer medicines are not available for patients. This research will focus on availability, pricing and funding of HCMs. The research will determine the proportion of funded HCMs by NHS relative to those approved for use in other EU countries. It will also explore the perception of health care professionals regarding the issue and will compare the prices of HCMs between the UK and other EU nations. The project will contribute towards a solid empirical and analytical foundation for future decision-making.

Contact Professor Zaheer Babar [email protected] 01484 471471

Development and Characterisation of Pharmaceutical Formulations Using Novel Materials to Treat Gastro-oesophageal Reflux Disease (GORD)

GORD is a clinical condition arising from chronic exposure of the oesophagus to stomach acid, associated with symptoms of heartburn and acid reflux. Untreated, it can lead to oesophagitis, Barrett's oesophagus, and even oesophageal cancer. Studies at the University of Huddersfield have identified a new treatment for GORD using a novel formulation approach. This project will aim to develop novel formulations and systematic characterisation using rheology, texture analysis, chemical mapping using AFM, tomography, hydration, erosion, dissolution, chemical and physical characterisation including spectroscopic and analytical techniques. It is expected that the project will lead to industrial collaboration therefore applicants should have a strong interest in pharmaceutical development.

Contact Dr Muhammad Ghori [email protected] 01484 473295

Protection against Alzheimer’s disease by sparing oestrogen receptors involved in the development of breast and gynaecological cancers

Recent studies have indicated an association between cancer and Alzheimer’s disease (AD), both malignant diseases with incidence numbers increasing at a significant rate. Oestrogens are neuroprotective, however, there are significant cancer risks associated with these hormones. New compounds, synthesised at the University of Huddersfield, are hypothesised to produce neuroprotective effects without inducing cancer risks. The aim of this study is to investigate neuroprotection and prevent cancerous growth using human neuronal and carcinoma cells. We attempt to develop novel therapeutic strategies for AD with no risk of cancer development. A wide range of biochemical and molecular techniques in cell culture models will be used.

Contact Dr Farideh Javid [email protected] 01484 472543

Gastric balloon: a non-invasive weight loss intervention

Obesity is one of the major health concerns in developed countries. Weight-loss surgery is the gold standard but is expensive and irreversible. Gastric balloons are an alternative to weight loss surgery. This approach is cost effective compared with other surgical interventions but is still expensive and cannot be offered outside a hospital setting. This project aims to redesign gastric balloons to overcome limitations associated with the current technology. The project will include developing a series of pharmaceutical formulations and their detailed characterisation, for example; swelling, gastric-stability, rheology, buoyancy, etc. It is anticipated that project will lead to industrial/clinical collaborations to further the technology in preclinical and clinical trials.

Contact Dr Hamid Merchant [email protected] 01484 472387

How to Apply

If you are interested in any of these projects please contact the relevant supervisor for an informal discussion. To apply, please send an email outlining your motivation and experience to the supervisor, including a CV and the names of two referees by 26 March 2017 (copy to [email protected]).

You should also complete an on-line application.

Candidates may direct general enquiries to Dr Dougie Clarke, Director of Graduate Education in the School of Applied Sciences [email protected] 01484 473142. General information about the School and research at the University is available on our website.

The studentships are open to citizens of the UK or EU only, and cover the full cost of tuition fees and an annual tax-free bursary of £14,553 for three years (RCUK rates). Successful applicants will have a very good first or upper second degree in a relevant subject.

PhD Studentships in Pharmacy

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