For details of how to apply for any of the projects outlined below please click on the following hyperlink: https://www.findaphd.com/search/PhDDetails.aspx?CAID=2816
Being able to predict the behaviour of drugs that are administered by intramuscular injection is not yet possible. Only once the medicine is injected in to humans can scientists determine how fast, and how much of the drug will be delivered to the site of action. There are many reasons why an analytical system to mimic this process would be beneficial including the avoidance of animal testing as well as improved drug development. This project will develop a chemical based model system that will be tested using known drugs to optimise its ability to predict drug behaviour to create an alternative way of characterising new medicines thus providing a viable alternative for the pharmaceutical industry. Applicants are not required to have previous experience in pharmaceutical analysis as all necessary training will be provided.
Contact: Dr Laura Waters [email protected] 01484 472190
Targeting using mucoadhesive dosage forms enhances the therapeutic efficacy of drugs/macromolecules for treatment of GI tract, lungs, nose, eye, reproductive tract disorders. This project involves the development of novel mucoadhesive polymers e.g. thiomers, targeted to mucosal sites and design of models to simulate diffusion/permeation across mucosae, limiting requirements for animals and problems associated with the degradation of native mucus. In addition, mucoadhesive polymers will also be investigated for potential forensic applications as they have previously been shown to interact with fingermarks, for example. The project is interdisciplinary and should be extremely relevant to those wanting a career in pharmaceutical development, chemical engineering or polymer science. Full training will be given in a wide range of techniques including HPLC, MS, NMR, XRD, FT-IR, DSC, NTA, microscopy (SEM, AFM, Confocal, fluorescence), tensiometry, rheology, particle size analysis, cell culture and dissolution testing.
Contact Dr Adeola Adebisi [email protected] 01484 473856
It is known that aggressive early treatment may deter long-term damage that is associated with rheumatoid arthritis. This project will explore utilisation patterns of medicines used for the treatment of rheumatoid arthritis using large primary care databases. The potential economic burden of these medicines as well as health outcomes associated with these medicines will be investigated. In view of effectiveness of available therapeutic options, the project will be key to provide robust information to prescribers, healthcare professionals and to funding bodies.
Contact Dr Syed Shahzad HASAN [email protected] 07568497278
Diabetes is one of the major healthcare concerns in UK and is a significant cost to NHS. According to the NHS, there are 3.9 million people living with diabetes in UK, which is twice as many than in 1996. Like other diseases, an early diagnosis is very important for diabetes to avoid disease progression and risk for cardiovascular disease. Identification of high risk groups who may develop diabetes in next five years, therefore, is a key strategy to prevent developing disease and hence the national diabetes prevention program (NDPP) was launched in 2016 by the NHS and Public Health in England. The program significantly depends on the risk scoring system, taking inputs from age, sex, ethnicity, blood pressure, family history of diabetes, body mass index and waist measurements. This project is aimed to improve the current risk-scoring system in UK by developing a holistic approach to include visceral obesity into a robust risk scoring system to identify individuals at high risk of developing diabetes in UK, such as South Asians.
This project is in collaboration with Professor Jonathan Wheat at the Academy of Sport and Physical Activity at the Sheffield Hallam University, and shall involve travel between the sites. The ideal candidate should have a relevant degree with strong interest in the subject area and should be willing to commute to the Centre of Sports Engineering Research at Sheffield Hallam for data collection using 3D Surface Scanners. The project involves body measurements, image analysis, and development/ validation of risk scoring algorithms for diabetes.
Contact Dr Hamid Merchant [email protected] 01484 472387