Dr W Haerty
No more applications being accepted
Competition Funded PhD Project (European/UK Students Only)
About the Project
We offer a highly collaborative PhD project between three research groups (Haerty: bioinformatics, Wheeler: cell and developmental biology, Edwards: developmental and molecular biology) combining computational biology and experimental developmental biology to investigate the diversity and functional during Vertebrate development of alternatively spliced transcripts originating from genes of the ADAMTS (A Disintegrin and Metalloproteinase with /thrombospondin type I motifs) family. The PhD student will gain expertise in computational biology, large datasets analysis, transcriptomics, arising long read sequencing technologies, genetics, microscopy and developmental biology gaining highly transferable skills.
Nearly all the genes in human undergo alternative splicing, the process through which different transcripts are generated from a single gene. Despite the observation of the universality of alternative splicing in Eukaryotes, tissue and developmental stage specific regulation of splicing, and the importance of this mechanism in fundamental biological processes, much remain to be discovered regarding the function of alternatively spliced transcripts.
The aim of the project is to provide a novel understanding of the importance and regulation of alternative splicing in the ADAMTS gene family during development. ADAMTS are secreted enzymes with roles in tissue morphogenesis and patho-physiological remodeling. The student will apply combined computational and experimental approaches to annotate and functionally characterize transcripts through in-situ expression assays and gene manipulations in Xenopus.
This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 8th, 9th or 10th January 2019.
The NRP DTP offers postgraduates the opportunity to undertake a 4-year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply.
For further information and to apply, please visit our website: www.biodtp.norwichresearchpark.ac.uk
Funding Notes
For funding eligibility guidance, please visit our website: http://biodtp.norwichresearchpark.ac.uk/how-to-apply/funding-and-eligibility. Full Studentships cover a stipend (UKRI rate: £14,777pa – 2018/9), research costs and tuition fees at UK/EU rate and are available to UK and EU students who meet the UK residency requirements.
Students from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award. Students in receipt of a fees-only award will be eligible for a maintenance stipend awarded by the NRPDTP Bioscience Doctoral Scholarships. To be eligible students must meet the EU residency requirements.
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