Elucidating the roles of RNA-protein regulatory networks in centrosome biology and the cell cycle

Our research aims to elucidate the molecular mechanisms that control cell division in development and cancer. In several tissues, centrosomes act as key microtubule organizing centres both in proliferating and differentiated cells. Moreover, because centrosomes organise the mitotic spindle poles and template the assembly of primary cilia (signalling organelles with diverse functions), centrosome numbers must be strictly controlled in cells. Indeed, in cultured cells and during development, both loss and gain of centrosomes can lead to mitotic delay, chromosomal instability, cell cycle arrest and apoptosis. Centrosome amplification can also initiate invasion and tumourigenesis. The goal of this project is to test the hypothesis that centrosomes exhibit tissue-specific roles, especially in cell cycle control. The work will involve identification and characterisation of new RNA-protein regulatory networks underscoring these functions. Proteomics, molecular biology and microscopy imaging will be integral to the success of the project.

A degree in biochemistry, molecular or cell biology is essential and previous research experience is desired.