Synthetic biology-enabled new generation biosensors to tackle global health and environmental challenges

The traditional laboratory-based analytical assays for bacterial pathogens and environmental toxins are expensive, time consuming and normally require specialised personnel and complex equipment. This restricts their use in resource limited areas and developing countries where lack sufficient skilled personnel and healthcare facilities to rapidly identify the risks. There is therefore an urgent need to provide simple cost-effective, fast on-site sensing solutions for pathogens (e.g. diarrhea-related Shigella flexneri), toxins (e.g. arsenic or pesticides) and metabolites (e.g. phenylalanine in phenylketonuria) associated with fatal infectious/metabolic diseases and contaminated water or land resources.
This project aims to use innovative synthetic biology approaches to develop new generation biosensors to address these daunting global health and environmental challenges. In particular, we will develop robust, fast, inexpensive and portable cell-free/paper-based biosensors that are readily deployable in the field with minimal human intervention and/or resources. The project is based on our prior ample experience and expertise in engineering synthetic cell-based biosensors for environmental toxins and pathogens with programmable sensitivity and selectivity. Advanced signal processing and amplifying gene networks may be used within these sensor circuits to substantially boost sensor sensitivity to fulfil their real world detection requirements. Novel encapsulation and packaging methods will also be developed to significantly increase the robustness, stability and shelf life of the resulting sensors. The technology developed will find diverse applications in environmental, biotechnological and medical settings.
The project will provide you a comprehensive training of advanced molecular and genetic tools, innovative microbiology and bioelectronics techniques and computational skills. This project will be supervised by Dr Baojun Wang, a group leader in the world-leading Centre of Synthetic and Systems Biology of the University of Edinburgh, giving the student an interdisciplinary research experience in the fields of synthetic biology and global health as well as the opportunity of working with relevant project industrial partners.

Further information about the lab can be found at http://wang.bio.ed.ac.uk/ and informal enquiries may be made to [Email Address Removed].