Wellcome Trust Featured PhD Programmes
University of Glasgow Featured PhD Programmes
Imperial College London Featured PhD Programmes
King’s College London Featured PhD Programmes
University of Reading Featured PhD Programmes

The evolutionary ecology of disease transmission: how will vector control programmes change parasite life histories?

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Prof S Reece
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Parasites live in inside the bodies of others, with whom they are engaged in a life-and-death struggle. The Reece lab uncovers the strategies parasites have evolved to cope with the challenges and opportunities of their lifestyle by asking “what makes a successful parasite and what are the evolutionary limits to their success?”. Specifically, we investigate how parasites maximise "survival" and "reproduction". These fitness components underpin the symptoms and transmission of diseases.
Most disease research focuses on interactions between parasites and their hosts. Analogous studies of interactions between parasites and vectors have been largely neglected, despite the fact that vectors are responsible for spreading disease. Clearly, to fully understand the evolution of vector-born parasites it is necessary to ask how they solve the challenges of living in hosts and in vectors. This is especially important for malaria parasites whose vectors are changing in response to vector-control programs (e.g., bed nets, insecticides). Whilst the evolutionary responses of malaria-transmitting mosquitoes to vector-control are being monitored, the knock-on consequences for parasite evolution have been overlooked. Just like drugs or vaccines administered to hosts, vector-control represents an ecological perturbation aimed at reducing parasite fitness. History clearly illustrates that attempts to reduce the survival and/or transmission of malaria parasites is usually met with counter-evolution (e.g., drug resistance mutations and phenotypic tolerance). Parasite counter evolution to vector-control may be constrained or facilitated, depending on the amount of genetic variation and plasticity underpinning parasite phenotypes. Anticipating parasite evolution will inform monitoring strategies for current control programs as well as uncovering novel new vector-control strategies.
Malaria is transmitted by Anopheline mosquitoes and their control centres on long-lasting insecticide treated bed nets and indoor residual spraying. Insecticides are implicated in causing: the evolution of resistance mutations to target sites and detoxification mechanisms, shifts in feeding schedule and location, altered host preference, changes in the relative importance of different mosquito species as vectors, and shorter lifespan. Predicting how parasites will respond to such changes in vector populations requires knowledge of: (a) The impacts of interventions on parasites directly (e.g. do insecticides kill parasites?). (b) How parasite fitness is affected by changes in vector genotypes and phenotypes (e.g. insecticide resistance, biting time-of-day, lifespan, vector species). (c) How much plasticity and genetic variation exist in parasite populations for heritable traits, including fitness, that are affected by vector-control. (d) Whether parasite traits affected by vector-control are governed by trade-offs or co-variances that affect responses to selection.

This PhD will open the black box of what life inside mosquito vectors is like and develop a novel field by revealing the genetic and environmental drivers of parasite transmission to, and from, the vector. This project will use malaria parasites of rodents and mosquitoes to integrate developments from different biological disciplines into an evolutionary framework. Malaria parasites are an ideal model system because well-controlled laboratory experiments that perturb the environments parasites experience within mosquito vectors can easily be carried out. The experiments will reveal the genetic and environmental drivers of parasite transmission to, and from, the vector.

http://www.reecelab.science
The PhD student will be joining a well-resourced lab with a technician, graduate research assistant and lab manager, 3 other PhD students, and 3 postdocs. Thus, the student will receive considerable intellectual and practical support to develop their research project. Our work to date suggests there are multiple novel and tractable directions for this PhD project to take and the student will be encouraged to decide which lines of enquiry to follow and to develop their own interests during the PhD.

Funding Notes

This opportunity is only open to UK nationals (or EU students who have been resident in the UK for 3+ years immediately prior to the programme start date) due to restrictions imposed by the funding body.

The “Apply online” button on this page will take you to our Online Application checklist. Please complete each step and download the checklist which will provide a list of funding options and guide you through the application process.

If you would like us to consider you for one of our scholarships you must apply by 12 noon on 9 November 2018 at the latest.

References

Lefevre et al 2013 PLOS Paths 9
Lefevre et al 2017 Evol Appl 11
Rund et al 2016 Insects
Lambrechts 2010 PLOS Paths 6
Ohm et al 2018 Parasit Vectors 11

How good is research at University of Edinburgh in Biological Sciences?

FTE Category A staff submitted: 109.70

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities


FindAPhD. Copyright 2005-2018
All rights reserved.

Let us know you agree to cookies

We use cookies to give you the best online experience. By continuing, we'll assume that you're happy to receive all cookies on this website. To read our privacy policy click here

Ok