Prof W Balachandran
No more applications being accepted
Funded PhD Project (Students Worldwide)
About the Project
You will work on a project to investigte electrostatic properties of pharmaceutical aerosols generated by pressurized metered dose inhalers (pMDIs). It has been recognised that when the aerosols are delivered by pMDIs, they are electrically charged and consequently the medicament deposition in the human lung is influenced by the level and polarity of charge. The process of charge acquisition during aerosol formation is poorly understood. The charge acquisition mechanism is complex as the contact and tribo-electrification will take place and it is difficult to identify which of these mechanisms is dominant at which location. This complex process depends on the electronic work function of the surfaces involved. Furthermore, the flash boiling that takes place within the valve stem and valve orifice will play a major role in the atomisation process. In order to better understand the complex charge acquisition mechanisms, a systematic study of the materials and processes involved need to be carried out. If deep knowledge of the mechanisms involved can be understood, it would then be possible to even control the characteristics of the aerosol that exit from the devices so that specific site lung deposition of the active pharmaceutical ingredients (API) may be achievable.
Please contact Professor Wamadeva Balachandran at [Email Address Removed] for an informal discussion about the project.
Funding Notes
The studentship is for a period of 3 years and the successful applicant will receive an annual stipend of £16,777 plus payment of their full time Home/EU tuition fees.
A successful international applicant will receive payment of their full time international tuition fee and a maximum contribution to living costs of £5,500, adjustable annually.
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