Epigenetic transitions in Development at University of Edinburgh on FindAPhD.com

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Prof R Meehan No more applications being accepted Competition Funded PhD Project (European/UK Students Only)

About the Project

This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.

Project details

Epigenetic modifications of histones and DNA in the cell nucleus are essential for embryo development by regulating active and repressive chromatin states that propagate gene activity patterns in cell lineages and regulate overall nuclear architecture and chromosome function. The appearance of nuclear condensed chromatin in mouse embryogenesis coincides with differentiation and a restriction in developmental potential but its causal involvement in these processes remains unclear.

We hypothesise that epigenetic repression pathways act in a three-dimensional and signalling context in the embryo, which are disrupted when embryonic stem cells are cultured in a dish. We will explore this using a variety of experimental and advanced imaging approaches.

For further information on how to apply for this project, please visit: https://www.ed.ac.uk/mrc-human-genetics-unit/graduate-research-and-training/mrc-four-year-phd-programme-human-genetics-genomic

Funding Notes

For full funding (fees and stipend) students must be UK or EU citizens who have been resident in the UK for 3 years prior to commencement.

However, EU students with quantitative or multidisciplinary skills are eligible for full funding.

Where will I study?

University of Edinburgh

One of the world''s top universities, consistently ranked in the world top 50 and placed 20th in the QS World University Rankings 2020. We provide a stimulating working, learning and teaching environment with access to excellent facilities and attract the world''s best, from Nobel Prize winning laureates to future explorers, pioneers and inventors.

Epigenetic transitions in Development

University of Edinburgh College of Medicine and Veterinary Medicine

This project is no longer listed on FindAPhD.com and may not be available.

About the Project

Funding Notes

Where will I study?

University of Edinburgh

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