A genome-wide view of posttranscriptional processes
A typical yeast cell contains around 40,000 molecules of messenger RNA (mRNA), whereas a typical mammalian cell more than 100,000. All these mRNAs need to be processed, exported to the nucleus to the cytoplasm, translated, and eventually degraded. This means that even in a simple eukaryotic cell - such as yeast – there are thousands of posttranscriptional events taking place simultaneously at any given time. We are interested in how these posttranscriptional events are coordinated with each other and with transcriptional control.
We use the fission yeast Schizosaccharomyces pombe to study these questions, and address them with state-of-the-art genomic methods, classical and molecular genetics, and cell biological approaches. There are available projects in the areas of the ’peptidome’ of fission yeast and genome-wide translational control. We are studying translation using both single-gene approaches as well as genome-wide methods (such as RNA-seq ribosome profiling). A PhD project could involve a combination of both approaches to study translational control in response to environmental signals.
Our current model system is fission yeast, but we are starting to use the apicomplexan parasite Toxoplasma for our experiments. Both model systems would be available for PhD projects.
I am a member of the BBSRC DTP Programme (View Website) and the Wellcome Trust PhD Programme in Developmental Biology (View Website). Both programmes offer fully-funded fellowships.
Duncan C and Mata J (2014) The translational landscape of fission yeast meiosis and sporulation. Nat Mol Struct Biol
Mata J (2013) Genome-wide mapping of polyadenylation sites in fission yeast reveals widespread alternative
polyadenylation. RNA Biology 10 (8) 1-8
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FTE Category A staff submitted: 189.63
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