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Inhibiting protein-protein interactions in the early stages of amyloid formation

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  • Full or part time
    Prof S E Radford
    Prof Sobott
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Amyloidosis is a pathological condition associated with the aggregation of proteins into fibrils. Despite the importance of amyloid diseases in today’s society, therapies remain remote.

In this project we will use directed evolution, biochemical, biophysical assays, including native mass spectrometric methods and, by combining these will cell biology, aim to develop new inhibitors of amyloid disease and to determine their mechanism of action in structural detail. Focusing on amylin (IAPP) involved in type II diabetes and Abeta involved in Alzheimer’s disease we will use biochemical and biophysical assays to determine the structure of the amyloid precursor, the mechanism of aggregation and the action of aggregation inhibitors that modulate the aggregation process.


More details about research in our research groups can be found at:
http://bmbsgi10.leeds.ac.uk
http://www.astbury.leeds.ac.uk.

Please contact [email protected] for more information.

Funding Notes

BBSRC White Rose Mechanistic Biology DTP 4 year studentship.
Studentships covers UK/EU fees and stipend (c.£14,296) for 4 years to start in Oct 2017. Applicants should have/be expecting at least a 2.1 Hons. degree in a relevant subject. EU candidates require 3 years of UK residency in order to receive full studentship.
Not all projects advertised will be funded; the DTP will appoint a limited number of candidates via a competitive process and the projects selected by the successful candidates will be funded.
There are 2 stages to the application process. Please see our website for more information: http://www.fbs.leeds.ac.uk/postgraduate/phdopportunities.php

References

We have published several exciting papers on this topic recently. A full list of publications can be found on the web site http://www.astbury.leeds.ac.uk and then look up Radford.
Further details about the Radford group can be found at http://www.astbury.leeds.ac.uk/bmbsgi10

How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities
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