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database and may not be available.
International students with funding are currently hosted by the laboratory. Students with self-funding will be considered.
A comparison of key aspects of gene regulation in Streptomyces coelicolor and Escherichia coli using nucleotide-resolution transcription maps produced in parallel by global and differential RNA sequencing. (2014). Romero DA et al. Mol Microbiol. 2014 Sep 30. doi: 10.1111/mmi.12810.
Direct entry by RNase E is a major pathway for the degradation and processing of RNA in Escherichia coli (2015).
Clarke JE et al. Nucleic Acids Res. 2015 Feb 1;42(18):11733-51. doi: 10.1093/nar/gku808.
Adjacent single-stranded regions mediate processing of tRNA precursors by RNase E direct entry (2014).
Kime L, Clarke JE et al. Nucleic Acids Res. 2014 Apr;42(7):4577-89. doi: 10.1093/nar/gkt1403.
The regulation of the secondary metabolism of Streptomyces: new links and experimental advances (2011). van Wezel GP, McDowall KJ. Nat Prod Rep. 2011 Jul;28(7):1311-33. doi: 10.1039/c1np00003a
Kime L, Jourdan SS, Stead JA, et al. (2010). Rapid cleavage of RNA by RNase E in the absence of 5' monophosphate stimulation. Mol. Microbiol. 76: 590-604.
Nothaft H et al. (2010). The permease gene nagE2 is the key to N-acetylglucosamine sensing and utilization in Streptomyces coelicolor and is subject to multi-level control. Mol. Microbiol. 75: 1133-1144.
Carpousis AJ, Luisi BF, McDowall KJ (2009) Endonucleolytic Initiation of mRNA Decay in Escherichia coli. Prog. Mol. Biol. Transl. Sci. 85: 91-135.
Resch A, Afonyushkin T, Lombo TB, et al. (2008) Translational activation by the noncoding RNA DsrA involves alternative RNase III processing in the rpoS 5 '-leader. RNA 14: 454-459.
Stead JA, McDowall KJ (2007) Two-dimensional gel electrophoresis for identifying proteins that bind DNA or RNA. Nature Protocols 2: 1839-1848.
Jourdan SS, McDowall KJ (2008) Sensing of 5 ' monophosphate by Escherichia coli RNase G can significantly enhance association with RNA and stimulate the decay of functional mRNA transcripts in vivo. Mol. Microbiol. 67: 102-115.
Callaghan AJ, Marcaida MJ, Stead JA, McDowall KJ, Scott WG, Luisi BF. (2005) Structure of Escherichia coli RNase E catalytic domain and implications for RNA turnover. Nature. 437:1187-91.
Uguru GC, Stephens KE, Stead JA, Towle JE, Baumberg S, McDowall KJ. (2005) Transcriptional activation of the pathway-specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor. Mol Microbiol. 58:131-50.
FTE Category A staff submitted: 60.90
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