What constitutes ‘effective’ exercise for Alzheimer’s Disease? A project to assess if exercise can alter markers of disease pathology

Alzhemier’s Disease (AD) is the most common form of dementia in the UK. There is no one cause, it is a multi-factoral disease. Oxidative stress is believed to be one of the factors or pathologies which contributes to AD. Recently it has become clear that lifestyle factors, such as diet and exercise in mid and later life can affect an individual’s risk of developing AD. Lifestyle still plays a role once the disease is diagnosed too. We have previously shown that markers of oxidative stress and inflammation are altered in AD. We would now like to assess the impact of exercise upon some of these markers in mid-life to investigate potential effective exercise to reduce risk of developing AD.