• University College London Featured PhD Programmes
  • University of Nottingham Featured PhD Programmes
  • Ross University School of Veterinary Medicine Featured PhD Programmes
  • University of Warwick Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
  • Brunel University London Featured PhD Programmes
  • King Abdullah University of Science and Technology (KAUST) Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
University of Strathclyde Featured PhD Programmes
Cranfield University Featured PhD Programmes
Cardiff University Featured PhD Programmes
Macquarie University Featured PhD Programmes
University of Reading Featured PhD Programmes

Control of synaptobrevin retrieval by synaptophysin

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Dr M Cousin
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (UK Students Only)
    Competition Funded PhD Project (UK Students Only)

About This PhD Project

Project Description

Synaptobrevin-2 and synaptophysin are the two most abundant proteins present on a synaptic vesicle (SV). Synaptobrevin-2 is a protein essential for SV exocytosis, whereas until recently synaptophysin was a protein of unknown function. We have recently shown that synaptophysin is essential for the specific retrieval of synaptobrevin-2 from the plasma membrane after exocytosis, however may questions remain unanswered. These include, what controls the retrieval of synaptophysin itself, how does synaptophysin interact with synaptobrevin-2, and does synaptophysin also control the retrieval of non-canonical synaptobrevins (thought to define different modes of exocytosis)? Approaches used will include primary neuronal cultures derived from synaptophysin knockout mice, monitoring of SV recycling using fluorescent genetic and chemical reporters, ultrastructural analysis using transmission electron microscopy, recombinant protein expression, classical biochemistry and molecular biology technologies.


Gordon S.L., Leube R.E. and Cousin M.A. (2011) Synaptophysin is required for synaptobrevin retrieval during synaptic vesicle endocytosis J. Neurosci. 31: 14032-14036.
Clayton E.L., Sue N., Smillie K.J., O’Leary T., Bache N., Cheung G., Cole, A.R., Wyllie D.J, Sutherland C., Robinson P.J. and Cousin M.A. Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles. (2010) Nature Neurosci. 13: 845-851.

Share this page:

Cookie Policy    X