Helminth proteases involved in tissue invasion, feeding and immunomodulation
Helminth parasites cause enormous mortality and morbidity globally, especially in poor regions of the world. The ability to infect and establish long-term disease in humans is directly related to the power by which these parasites can penetrate and feed on host tissues, and to suppress the function of immune effector cells. Proteases are pivotal to both these functions. In this project, two major animal and human diseases (fascioliasis and schistosomiasis) will be investigated; we will isolate several novel proteases and investigate them at a phylogenetic, genomic, biochemical and structural levels. We will also use silencing methods (inhibitors and RNA interference) to probe their function in the parasite-host interaction.
This project is offered by the Institute for Global Food Security at the Queen's University School of Biological Sciences and will be supervised by Dr Mark Robinson and Professor John Dalton. The student will be based at the Queen's University Medical Biology Centre.
Funding is for a three-year PhD project to be begun in September 2013 and completed by the end of August 2016.
The position is fully funded by a DEL studentship. PLEASE NOTE THAT ONLY APPLICATIONS FROM THE UK ARE ELIGIBLE.
Applicants should have a primary degree (2.1 or 1) and/or a MSc in an appropriate discipline (e.g. Biology, Molecular Biology, Biochemistry, Zoology).
For informal discussions about the project and suitability contact Dr Mark Robinson ([email protected])
*** PLEASE NOTE THAT THE QUEEN'S UNIVERSITY APPLICATION PORTAL IS CLOSED FOR MAINTENANCE BETWEEN 5.00 PM ON FRIDAY 22 MARCH AND 9.00 AM ON MONDAY 25 MARCH. THEREFORE, APPLICATIONS CANNOT BE SUBMITTED DURING THIS PERIOD ***