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Understanding cancer using novel Affimer binding proteins

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

The specificity of protein-protein interactions is key to the successful execution of virtually every biological process yet molecular biology tools to block these interactions are lacking. This project focuses on developing biological tools against a class of protein domains known to be important for mediating protein-protein interactions during cellular signaling in cancer. These biological tools will be used to block protein function, visualisation of the biomarker using imaging techniques such as super-resolution microscopy, and/or be used to inform drug design using structural information and high-throughput small molecule screening.

The student will utilize Affimer libraries (https://elifesciences.org/articles/24903) to isolate reagents against different domains and test their ability to block protein function. This will involve performing phage display, expressing proteins, developing microarrays, and performing high-throughput high content phenotypic screening. Depending on target this may also involved performing X-Ray crystallography for structural studies as well as in silico small molecule design with collaborators in Chemistry.

You will be joining a large growing team in the Tomlinson lab, consisting of 10 PhD students, 3 PDRAs and 2 technicians, in a productive and exciting environment at the University of Leeds. Our group is consistently publishing high impact papers using Affimers and has recently published in journals such as eLife, PNAS, Science Signalling, Scientific Reports and Biosensors and Bioelectronics. Please see http://dctomlinson.wixsite.com/laboratory for more details about papers, the group and the type of projects being studied in our group.

Funding Notes

Applicants should have, or be expecting to receive, a 2.1 Hons degree in a relevant subject which could be in Chemistry or Biology related disciplines and have the ability to self-fund a PhD or Masters by Research


How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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