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Understanding signaling cascades: developing biological tools against a class of protein domains

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  • Full or part time
    Dr D Tomlinson
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

The specificity of protein-protein interactions is key to the successful execution of virtually every biological process yet molecular biology tools to block these interactions are lacking. This project focuses on developing biological tools against a class of protein domains (Src homology 2 domains, SH2) known to be important for mediating protein-protein interactions during cellular signaling.

The student will work closely with Avacta Life Sciences and utilize non-antibody binding protein libraries to isolate reagents against SH2 domains and testing their ability to block protein function. This will involve performing phage display, expressing proteins, developing microarrays, and performing high-throughput high content phenotypic screening.

Funding Notes

To start in Oct 2017. Applicants should have, or be expecting to receive, a 2.1 Hons degree in a relevant subject.

This project is eligible for BBSRC funding. We are advertising a range of projects and funding will be awarded to the best candidates. The funding covers fees at UK/EU level plus a stipend of £14,553 for 4 years. Please note that candidates must have been resident in the UK for the last 3 years to be eligible for full funding; candidates who have not been resident in the UK are eligible for a fees-only studentship.

Please apply online: https://studentservices.leeds.ac.uk/pls/banprod/bwskalog_uol.P_DispLoginNon

How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

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