Investigating the role of protein hydroxylation in genome stability and cancer.

An exciting PhD opportunity is available in the Institute of Cancer and Genomic Sciences, University of Birmingham, to characterise the role of protein hydroxylases in Genome Stability and Cancer.

Protein hydroxylation is an exciting new post-translational modification that is emerging as a key player in a variety of disease processes, including Cancer. For this reason, the hydroxylase enzymes are attracting significant interest from the academic and pharmaceutical research communities.

This project will use a multi-disciplinary approach to characterise novel cancer-associated protein hydroxylases, with particular emphasis on understanding their role in DNA damage, replication and genome stability.

The Coleman Lab are experts in tumour cell biology and hydroxylation. Selected recent publications include; Feng et al Mol Cell, 2014; Ge et al Nat Chem Bio, 2012; Ploumakis et al Mol Cell, 2015; and Thienpoint et al Nature, 2016.

Group Pages:
http://www.birmingham.ac.uk/staff/profiles/cancer-genomic/coleman-matthew.aspx
http://www.birmingham.ac.uk/research/activity/cancer-genomics/research/oxygenases-cancer/index.aspx

Project enquiries and applications to: [Email Address Removed]

Applications should include; Cover letter outlining relevant experience and explaining interest in the project, CV, plus details of two referees.