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(MRC DTP) Feto-placental flow modelling from detailed vascular structural image analysis

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  • Full or part time
    Dr E Johnstone
    Prof Jensen
    Dr P Brownbill
    Dr Chernyaysky
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

We have developed a system to image the placental vasculature and published a preliminary study demonstrating differences in the structure of vessels in normal and abnormal placentas. This system uses microCT technology to image vascular casts of the placental vasculature tree. Our published study has only started to explore the potential of the imaging technology used and mathematical, statistical and computational approaches are now needed to characterise the vessel network structure to assess the relationship between placental structure and blood flow efficacy at the whole-organ level. We will Develop multi-scale models of the feto-placental circulation involving which we will in turn validate with ex vivo perfusion of whole placental lobules, and compare these more complex models in normal and abnormal placentas.

www.maths.manchester.ac.uk/~ojensen
https://www.research.manchester.ac.uk/portal/en/persons/paul-brownbill(7ca3c8a6-ac97-44f1-8b8e-e37893fc6dac).html

Funding Notes

This project is to be funded under the MRC Doctoral Training Partnership. If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form - full details on how to apply can be found on the MRC DTP website www.manchester.ac.uk/mrcdtpstudentships

Applications are invited from UK/EU nationals only. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.

References

Whole organ vascular casting and microCT examination of the human placental vascular tree reveals novel alterations associated with pregnancy disease.
Junaid TO, Bradley RS, Lewis RM, Aplin JD, Johnstone ED. Sci Rep. 2017 Jun 23;7(1):4144. doi: 10.1038/s41598-017-04379-0.

Integration of computational modeling with membrane transport studies reveals new insights into amino acid exchange transport mechanisms.
Widdows KL, Panitchob N, Crocker IP, Please CP, Hanson MA, Sibley CP, Johnstone ED, Sengers BG, Lewis RM, Glazier JD. FASEB J. 2015 Jun;29(6):2583-94. doi: 10.1096/fj.14-267773. Epub 2015 Mar 11.

Image-Based Modeling of Blood Flow and Oxygen Transfer in Feto-Placental Capillaries.
Pearce P, Brownbill P, Janáček J, Jirkovská M, Kubínová L, Chernyavsky IL, Jensen OE.
PLoS One. 2016 Oct 27;11(10):e0165369. doi: 10.1371/journal.pone.0165369. eCollection 2016.

Dysregulated flow-mediated vasodilatation in the human placenta in fetal growth restriction.
Jones S, Bischof H, Lang I, Desoye G, Greenwood SL, Johnstone ED, Wareing M, Sibley CP, Brownbill P.
J Physiol. 2015 Jul 15;593(14):3077-92. doi: 10.1113/JP270495. Epub 2015 Jun 8.

Optimal villi density for maximal oxygen uptake in the human placenta.
Serov AS, Salafia CM, Brownbill P, Grebenkov DS, Filoche M.
J Theor Biol. 2015 Jan 7;364:383-96. doi: 10.1016/j.jtbi.2014.09.022. Epub 2014 Sep 27.

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