Blood Flow Modelling and Assessment of Fractional Flow Reserve in Stenotic Arteries
Medical Research Scotland
PhD Studentship Award
This project is one of 15 four-year PhD Studentships funded by Medical Research Scotland (MRS) (http://www.medicalresearchscotland.org.uk) to be delivered jointly by the named University and Company. The Studentships will provide the first-class academic and commercial training needed to equip the successful candidate for a science career in an increasingly competitive market.
"Fractional flow reserve derived through computational fluid dynamics: a non-invasive diagnostic measure to assess the importance of various arterial stenotic diseases" to be delivered by the University of Glasgow and Toshiba Medical Visualization Systems Europe Ltd (www.tmvse.com) [Company supervisor: Dr James Matthews].
The School of Engineering of the University of Glasgow is seeking a highly motivated graduate to undertake this exciting PhD research project .
Blood supply to different organs and tissues of the body can be reduced as a result of narrowing of the feeding blood vessels. Depending on the size and location of the lesions (plaques) that cause the narrowing of the blood vessels forming stenosis, the function of the organs/tissues may be impaired and will require intervention (removal of the plaques).
This PhD project aims to develop advanced computational fluid dynamics (CFD) models and use them to predict the severity of blood flow reduction caused by individual plaques. CFD models will use the information provided by medical imaging (computed tomography, CT and magnetic resonance imaging, MRI) and compute patient-specific blood flow patterns with results validated by measurement data. The study will cover blood flow modelling in different arterial beds with stenosis and assess fractional flow reserve (a physiological index determined from the ratio of the pressure distal to a stenosis relative to that before the stenosis).
The project will be led by Dr Manosh Paul at the School of Engineering and co-supervised by Dr Aleksandra Radjenovic (Institute of Cardiovascular and Medical Sciences (ICAMS)) and Dr James Matthews (TMVS). The research will be carried out in close collaboration with collaborators based in ICAMS as well as clinicians based in the Glasgow Royal and Western Infirmary Hospitals.
The student will benefit from multiple placement opportunities in the Company in Edinburgh where s/he will work closely with the lead industry supervisor and his colleagues. The student will also learn basic safety and how to work with anonymised clinical data and will receive a coordinated programme of essential research training and skills, including writing, presentation and other generic transferable skills offered by the College of Science and Engineering. The student will also have the opportunity to attend and present research results in national/international conferences.
Informal enquiries about this Studentship can be made to Dr Manosh Paul ([Email Address Removed]). Please include a CV and enter the project title in the email subject.
Candidates must have obtained, or expect to obtain by September 2016, a first or 2.1 UK BEng/BSc Honours degree, or equivalent for degrees obtained outside the UK, in Mechanical, Aerospace or Biomedical Engineering, Applied Sciences, Mathematics, Applied Mathematics or a cognate discipline.
Candidates with a sound knowledge, interest, or background in fluid dynamics, numerical modelling, physiological/blood flow, computational fluid dynamics (CFD), programming are encouraged to apply.
The ideal candidate should be enthusiastic, self-motivated and have good organisational and interpersonal skills. Good communication skills (oral and written) in English are essential. The successful candidate is expected to conduct independent research leading to original contributions to the project.
Application for this PhD scholarship must be made to the admission team in the Recruitment and International Office, for admission as a postgraduate research (PGR) student, through the online system at the following link:
You need to upload all the documentation required for your application, the name of supervisor should be noted on the form and the project title and funding source (MRS Studentship) entered in the appropriate place.
Your application is to gain admission to our PGR programme, with the decision on this being based on your academic achievements. An offer of admission may be sent out before a decision on appointment to this PhD Studentship is made. Candidates applying for this Studentship will have their applications further vetted as to acceptability to this Studentship and will be interviewed by a panel including the supervisors and a Trustee of Medical Research Scotland before any decision is made.
Interviews are expected to take place 3-4 weeks after the closing date for applications.
It is anticipated that the PhD Studentship will start in October 2016.
PhD Studentship provides: an annual tax-free stipend of £16,500, increasing to £17,000 over the four years; tuition fees at UK/EU rates only; consumables; and contribution to travel expenses.
International fees are not covered. International students applying for the Studentship must provide evidence that they are able to finance the fee top-up required to the international fee level by the date of interview.
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