Dr MM Brinkmann
No more applications being accepted
Funded PhD Project (Students Worldwide)
About the Project
Objectives
•Determination of the proviral or antiviral role of cellular proteins induced after HCMV infection
•Detailed characterisation of the mechanism of action of selected antiviral or proviral proteins
Expected achievements
•Set up of a FACS-based assay to determine HCMV growth in cells overexpressing the set of proteins being induced after HCMV infection
•Cell biological and biochemical characterisation of selected anti- or proviral proteins
•Screen for HCMV proteins interacting with pro- or antiviral cellular proteins in the context of infection
•Generation of HCMV mutants lacking the identified HCMV proteins by BAC mutagenesis
•Characterisation of HCMV deletion mutant(s) in vitro
Planned Secondments
•University Medical Center Utrecht, The Netherlands; CRISPR/Cas technology
•Max Planck Institute Munich, Germany; Mass spectrometry
Requirements
•Solid background/expertise in cell biology, molecular biology, virology, and immunology
•Experience with biochemical methods and cloning, ideally in imaging and FACS analysis
•Ability to manage large experimental setups
•Ability to work in a team
Appointment details
Based on a full-time appointment, the duration of the appointment as a Marie Curie ITN fellow will be for a maximum period of 3 years. The PhD student will become member of the Graduate School of the Helmholtz Centre for Infection Research in Braunschweig and is expected to present her/his work at the annually PhD Retreat and to follow the mandatory training program of the Graduate School.
Manadatory Eligibility Criteria
Mobililty Rule
The researcher must not have resided or carried out his/her main activity (work, studies, etc) in the country of his/her host organization for more than 12 months in the 3 years immediately prior to his/her recruitment. Short stays, such as holidays, are not taken into account.
Career Stage
Early stage researcher shall at the time of recruitment be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree.
Contact details
Melanie M. Brinkmann, Professor
Viral Immune Modulation Research Group
Helmholtz Centre for Infection Research
Inhoffenstrasse 7
38124 Braunschweig
Germany
[Email Address Removed]
Funding Notes
Benefits
Monthly gross salary will be in accordance with the EC Marie Sklodowska Curie rates and will be paid by the host organization. The salary may be subjected to tax according to applicable national regulations. The positions are full-time and designed for a duration of 36 months.
Prospective date for start of project: Sep 1, 2016
The ESR cannot start before the project and candidate have been approved of the local PhD school as well as an approved residence and work permit (where applicable).
The ESR will be employed/enrolled locally in either Denmark, Germany, the Netherlands, United Kingdom, or Italy.
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