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Pulmonary oedema in health and disease: implications for breathing mechanics, muscle fatigue and exercise tolerance.

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  • Full or part time
    Dr Taylor
    Dr A.P. Benson
    Dr H B Rossiter
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Heart-failure is a complex clinical disorder in which the heart loses its ability to effectively pump blood around the body. The principal symptom of heart-failure is a dramatic reduction in the ability to perform mild exercise or routine day-today activities (e.g., walking to the shops). This is likely due to increases in the perceived difficulty to breathe and heightened symptoms of fatigue. Our recent research has shown that another complication of heart-failure is the accumulation of fluid in and around the lungs; this is known as pulmonary oedema. Whether pulmonary oedema contributes to the symptoms that ultimately lead to exercise cessation in heart-failure is unknown.
This project will use a multidisciplinary experimental (cardiopulmonary exercise testing, artificial nerve stimulation, oesophageal catheters, and ultrasonography) and computer modelling approach to investigate the effect of an experimental model of pulmonary oedema on: 1) breathing mechanics, lung volume regulation and ventilatory constraint; 2) exercise-induced locomotor and respiratory muscle fatigue; 3) exertional symptoms of breathlessness and fatigue; and 4) exercise tolerance, in healthy humans.

Funding Notes

4 year studentship, covering fees and stipend at RCUK level (£14,553 for 2017-18).
The PhD will start in Oct 2017. Applicants should have, or be expecting to receive, a 2.1 Hons degree in a relevant subject.

As part of the studentship the successful candidate will be required to undertake a minimum of 120 hours Sports and Exercise Sciences demonstrating per annum. The studentship would therefore suit candidates with an interest in teaching.

Please apply online here, including CV and references (we don't require a research proposal): https://studentservices.leeds.ac.uk/pls/banprod/bwskalog_uol.P_DispLoginNon
The PhD is based in the Faculty of Biological Sciences.

References

Taylor BJ, Snyder EM, Ceridon ML (PhD student), Wheatley CM, Chase SC (PhD student), Olson LJ, Johnson BD. Effect of β2-adrenergic receptor stimulation on lung fluid balance in stable heart-failure patients. J Heart Lung Transplant, 2016; Epub ahead of print (PMID: 27863863).

Taylor BJ, Carlson AR, Miller AD, Johnson BD. Exercise-induced interstitial pulmonary edema at sea-level in young and old healthy humans. Respir Physiol Neurobiol, 2014; 191: 17-25 (PMID: 24200644).

Taylor BJ, How SC, Romer LM. Expiratory muscle fatigue does not regulate operating lung volumes during high-intensity exercise in healthy humans. J Appl Physiol, 2013; 114: 1569-1576.

Benson AP, Grassi B, Rossiter HB. A validated model of oxygen uptake and circulatory dynamic interactions at exercise onset in humans. J Appl Physiol, 2013; 115: 743-755 (PMID: 23766506).

Keir DA (PhD student), Benson AP, Love LK (PhD student), Robertson TC (PhD student), Rossiter HB & Kowalchuck JM. Influence of muscle metabolic heterogeneity in determining the V O2p kinetic response to ramp-incremental exercise. J Appl Physiol, 2016; 120: 503-513 (PMID: 26679614).

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