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Structure-function, mechanism of action and therapeutic potential of enzymes involved in metabolic diseases

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  • Full or part time
    Dr Elton Zeqiraj
    Prof Ranson
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

We are excited to offer a PhD studentship to study enzymes involved in metabolic diseases.
The studentship offers a unique opportunity to experience research at a world-class academic institution and a multinational pharmaceutical company. An industry placement (minimum of 3 months) at Vertex Pharmaceutical’s site in Abingdon (Oxfordshire) will take place in year 3 or 4 of the studentship.

Techniques you will learn and use:
- Cryo-electron microscopy and/or X-ray crystallography for determining structures of proteins and protein-protein complexes
- Enzyme substrate kinetic measurements and enzyme inhibition
- Biophysical techniques such as Fluorescence Polarisation and calorimetry
- Cell biology and Cellular imaging assays

The project will suit someone interested in structural biology, enzymology, biochemistry and drug discovery. Experience in structural biology is not required and suitable training will be provided.

The Astbury Centre for Structural & Molecular Biology at the University of Leeds has excellent facilities for cryo-electron microscopy (two Titian Krios 300 kV), protein crystallography (crystallisation robots, automatic imaging), and protein production with expertise in multi-subunit expression in insect cell, yeast and bacterial expression systems. The Astbury Centre is also well-equipped with instrumentation for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering). Additionally, the University provides a state-of-the-art infrastructure for mammalian cell culture, high-throughput screening, imaging, mammalian genetics, chemical biology and proteomics.

The University of Leeds was named University of the Year 2017 by The Times and The Sunday Times’ Good University Guide.

As well as the stipend below, the successful candidate will receive an annual supplement of £2,500 from the industrial partner.

Informal enquires can be made to Dr Elton Zeqiraj ([email protected]).

Funding Notes

To start in Oct 2017. Applicants should have, or be expecting to receive, a 2.1 Hons degree in a relevant subject.

This project is eligible for BBSRC funding. We are advertising a range of projects and funding will be awarded to the best candidates. The funding covers fees at UK/EU level plus a stipend of £14,553 for 4 years. Please note that candidates must have been resident in the UK for the last 3 years to be eligible for full funding; candidates who have not been resident in the UK are eligible for a fees-only studentship.

Please apply online: https://studentservices.leeds.ac.uk/pls/banprod/bwskalog_uol.P_DispLoginNon

How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

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