About the Project
Openings for a prospective Ph.D. student in computational biology and biophysics are available in the group of Professor Ivaylo Ivanov at the Chemistry Department of Georgia State University, Atlanta, USA. We are looking for a highly motivated candidate to conduct research in molecular modeling that addresses critical problems in the biomedical arena, unified by the common theme of how cells accomplish faithful duplication of their genetic material. Research in our group has direct bearing on understanding the molecular basis of genetic integrity and the loss of this integrity in cancer and in degenerative diseases. The work involves large-scale molecular dynamics simulations and the application of hybrid modeling techniques to incorporate experimental data. For an additional perspective on this research, candidates are encouraged to visit our group website at https://ivanov-group.org
Interested candidates are welcome to contact Prof. Ivanov directly by email: [Email Address Removed] and should also apply to the GSU chemistry graduate program (http://chemistry.gsu.edu/graduate). Please attach a resume/CV and a brief cover letter to the application email.
Funding Notes
Support for graduate studies includes an annual stipend, benefits and a tuition waiver and generally comes from grants awarded to the group by the National Institutes of Health and the National Science Foundation. Georgia State Univ. is located in Atlanta - a multicultural city and one of the major metropolitan areas in the USA.
References
1. He, Y., Yan, C., Inouye, C., Fang, J., Tjian, R., Ivanov, I. & Nogales E. Structural basis of transcription promoter opening using single particle cryo-EM Nature (in press; 2016) doi:10.1038/nature17970
2. Hudson, W.H., Kossmann, B., de Vera, I.M., Chuo, S.W., Weikum, E.A., Eick G., Thornton, J., Ivanov, I., Kojetin, D.J., & Ortlund, E.A Distal substitutions drive divergent DNA specificity among paralogous transcription factors through a subdivision of conformational space Proceedings of the National Academy of Sciences USA (2016) 113, 326-331, doi:10.1073/pnas.1518960113
3. Xu, X., Yan, C., Kossmann, B. & Ivanov, I.* Secondary interaction interfaces with PCNA control conformational switching of DNA polymerase PolB from polymerization to editing Journal of Physical Chemistry B (2016) doi:10.1021/acs.jpcb.6b02082