Synthesis and testing of small-molecule heparin-mimics

Proteoglycans including heparin sulfate proteoglycan are involved in mediating many interactions between cells and their environments. Our group has had success in using small-molecule mimetics of heparin-like saccharides in reducing cell proliferation and motility which could have important applications in cancer therapy (Raiber et al, Bioorg. Med. Chem. Lett., 2007, 17, 6321). This project will involve the design, synthesis and evaluation of further small-molecule sulfated compounds in cancer, wound healing and endothelial dysfunction. Good organic chemistry skills will be needed and experience in biochemical testing would also be valuable.